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The impaired healing process is primarily driven by severe local inflammation, excessive oxidative stress, and restricted angiogenesis, with dysfunctional macrophage polarization being a central pathological factor. Inspired from mechanisms of apoptotic cell clearance and maintenance of tissue homeostasis in the body, herein we developed a sprayable apoptotic body\u2010mimic nanotherapeutic with macrophage\u2010targeting anti\u2010inflammatory and antioxidant properties, which consisted of the \u2018eat me\u2019 signal, phosphatidylserine\u2010exposing nanoliposome containing epigallocatechin gallate\u2010magnesium ion nanocomplexes (EGCG\u2010Mg@PSLs). Both in vitro and in vivo experiments demonstrated that macrophage\u2010targeted EGCG\u2010Mg@PSLs effectively alleviate inflammation, promote angiogenesis and collagen fiber formation, and accelerate wound closure. Network pharmacology analysis supported the therapeutic relevance of EGCG in DSI healing. Transcriptomic sequencing also revealed that EGCG\u2010Mg@PSLs likely modulate macrophage behavior via the MAPK signaling pathway and metabolic reprogramming. The results indicated that apoptotic body\u2010mimic nanotherapeutics with PS\u2010exposing shell and metal\u2013phenolic complex core represent a promising bio\u2010inspired therapeutic strategy for macrophage immunotherapy for chronic diabetic wounds.<\/jats:p>","DOI":"10.1002\/adhm.71665","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T09:37:18Z","timestamp":1788946638000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An Apoptotic Body\u2010Mimetic Nanoagonist for Synergistic Diabetic Wound Immunotherapy"],"prefix":"10.1002","volume":"15","author":[{"given":"Zhuan","family":"Wang","sequence":"first","affiliation":[{"name":"Division of Orthopaedics and Traumatology Department of Orthopaedics Nanfang Hospital Southern Medical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weilin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering College of Chemistry and Materials Jinan University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3166-5745","authenticated-orcid":false,"given":"Yusheng","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Orthopaedics and Traumatology Department of Orthopaedics Nanfang Hospital Southern Medical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihao","family":"Deng","sequence":"additional","affiliation":[{"name":"Division of Orthopaedics and Traumatology Department of Orthopaedics Nanfang Hospital Southern Medical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinmeng","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Orthopaedics and Traumatology Department of Orthopaedics Nanfang Hospital Southern Medical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanshu","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering College of Chemistry and Materials Jinan University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9486-902X","authenticated-orcid":false,"given":"Yuxuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Orthopaedics and Traumatology Department of Orthopaedics Nanfang Hospital Southern Medical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Meng","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Gastroenterology Department of Gastroenterology Nanfang Hospital Southern Medical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3964-4092","authenticated-orcid":false,"given":"Rong","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering College of Chemistry and Materials Jinan University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7913-0980","authenticated-orcid":false,"given":"Lei","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Orthopaedics and Traumatology Department of Orthopaedics Nanfang Hospital Southern Medical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(16)30190-5"},{"key":"e_1_2_10_3_1","volume-title":"Data Points Publication Series","author":"Margolis D. 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