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However, existing flexible electrodes typically exhibit either insufficient adhesion, resulting in unstable signal acquisition, or irreversible bonding that risks cortical injury upon removal. Here, a Zn\n                    <jats:sup>2<\/jats:sup>\n                    <jats:sup>+<\/jats:sup>\n                    \u2010regulated, reversibly adhesive flexible cortical electrode based on imidazole\u2010functionalized polydimethylsiloxane (PDMS\u2010IM) is presented. Hydroxyl groups distributed along the polymer backbone provide robust interfacial adhesion to neural tissue and metal electrodes, while terminal imidazole moieties enable reversible coordination with Zn\n                    <jats:sup>2<\/jats:sup>\n                    <jats:sup>+<\/jats:sup>\n                    ions. This coordination mechanism allows the electrode to maintain firm, conformal contact during electrophysiological recording and to detach rapidly and cleanly upon Zn\n                    <jats:sup>2<\/jats:sup>\n                    <jats:sup>+<\/jats:sup>\n                    exposure without leaving residue on the brain surface. The PDMS\u2010IM elastomer exhibits tunable mechanical properties (modulus of 10\u2013200\u00a0kPa), high stretchability, and low interfacial impedance, supporting stable cortical interfacing. In vivo epilepsy models demonstrate that Zn\n                    <jats:sup>2<\/jats:sup>\n                    <jats:sup>+<\/jats:sup>\n                    \u2010triggered detachment preserves both electrode integrity and cortical surface morphology while enabling reliable multichannel seizure monitoring. By decoupling strong tissue adhesion from atraumatic removal, this work establishes a controllable adhesive interface for transient neural implants and provides a practical strategy for safe cortical mapping in epilepsy surgery and related neurosurgical applications.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71682","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T04:26:46Z","timestamp":1788928006000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Switchable Cortical Interfaces with Ion\u2010Mediated Adhesion for In Vivo Seizure Mapping"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2284-4510","authenticated-orcid":false,"given":"Miao","family":"Tang","sequence":"first","affiliation":[{"name":"Jinshan Hospital State Key Laboratory of Brain Function and Disorders Institute for Translational Brain Research MOE Frontiers Center For Brain Science Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Zhang","sequence":"additional","affiliation":[{"name":"Jinshan Hospital State Key Laboratory of Brain Function and Disorders Institute for Translational Brain Research MOE Frontiers Center For Brain Science Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quansheng","family":"He","sequence":"additional","affiliation":[{"name":"Jinshan Hospital State Key Laboratory of Brain Function and Disorders Institute for Translational Brain Research MOE Frontiers Center For Brain Science Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyi","family":"Yang","sequence":"additional","affiliation":[{"name":"Jinshan Hospital State Key Laboratory of Brain Function and Disorders Institute for Translational Brain Research MOE Frontiers Center For Brain Science Fudan University Shanghai 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2834-2876","authenticated-orcid":false,"given":"Yousheng","family":"Shu","sequence":"additional","affiliation":[{"name":"Jinshan Hospital State Key Laboratory of Brain Function and Disorders Institute for Translational Brain Research MOE Frontiers Center For Brain Science Fudan University Shanghai 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