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We developed a biocompatible polyacrylamide\u2010DNA double\u2010network hydrogel (AuPt\/PEDOT\u2013DNA gel), cross\u2010linked by bis\u2010acrylamide and DNA duplexes, offering softness, stretchability, and self\u2010adhesiveness for direct skin application. Incorporating AuPt\/PEDOT, a cascade nanozyme with peroxidase\/oxidase\u2010mimicking activities and high photothermal efficiency, enables dual antibacterial action via ROS generation and photothermal therapy. Under near\u2010infrared irradiation, it achieves &gt;\u00a095% bacterial killing at safe concentrations and inhibits biofilm formation. Moreover, the intrinsic conductivity of the AuPt\/PEDOT\u2013DNA gel enables its operation as a flexible strain sensor that transduces skin deformation into motion signals, which can be harnessed to monitor periwound mechanical strain and provide active feedback to prevent excessive tissue tension, thereby complementing the antimicrobial and drug\u2010delivery functions with biomechanical protection during rehabilitation. It conforms to wounds, prevents drug leakage, and eradicates bacteria, enhancing prospects for advanced hydrogel dressings.<\/jats:p>","DOI":"10.1002\/adhm.71683","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T04:37:28Z","timestamp":1788496648000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Self\u2010Assembled AuPt\/PEDOT\u2013DNA Hydrogel Dressing: Simultaneous Bacterial Eradication and Exercise Behavior Monitoring"],"prefix":"10.1002","volume":"15","author":[{"given":"Qingyu","family":"Meng","sequence":"first","affiliation":[{"name":"College of Chemistry and Molecular Engineering Jiangsu Provincial University Key Laboratory of Intelligent Medical Sensing Materials and Devices State Key Laboratory of Materials\u2010Oriented Chemical Engineering Nanjing Tech University  Nanjing Jiangsu P. R. 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