{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T10:52:25Z","timestamp":1791543145791,"version":"4.3.4"},"reference-count":60,"publisher":"Wiley","issue":"37","license":[{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Despite increasing awareness of molecular subtypes of breast cancer, this heterogeneous malignant disease is still one of the leading causes of cancer death in women worldwide. Although receptor status may define the precise therapeutic targets, treatment of triple\u2010negative breast cancer (TNBC) relies mainly on chemotherapy with accompanying side\u2010effects. Thus, there is a need for the design and testing of more effective drug delivery systems and drug combinations. In this study, biomimetic self\u2010assembled bovine serum albumin (BSA) capsules (Cs) co\u2010loaded with a new drug combination, namely two drugs tanespimycin (T) and dasatinib (D), and natural compound quercetin (Q), were fabricated, and their anti\u2010breast cancer effects were assessed. (T\u2010D\u2010Q)\u2010BSA Cs were more active against TNBC cells compared to other types of breast cancer. Encapsulated drugs potentiated apoptotic cell death in TNBC cells compared to the effect of the free three\u2010drug formulation. In TNBC cells with mutated\n                    <jats:italic>TP53<\/jats:italic>\n                    , (T\u2010D\u2010Q)\u2010BSA Cs also induced necroptotic cell death accompanied by RAP1\u2010mediated stimulation of NF\u03baB activity and IL\u20106\u2010related proinflammatory response. (T\u2010D\u2010Q)\u2010BSA Cs also inhibited TNBC\u2010based tumor growth in two zebrafish xenograft in vivo models. In conclusion, the efficacy of (T\u2010D\u2010Q)\u2010BSA Cs as a novel therapeutic strategy to eradicate TNBC in vitro and in vivo was demonstrated.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71690","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T05:57:30Z","timestamp":1788847050000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Bio\u2010Inspired Albumin Platform for Synergistic Co\u2010Delivery of Tanespimycin, Dasatinib, and Quercetin and Enhanced Therapeutic Efficacy in Triple\u2010Negative Breast Cancer"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5354-3365","authenticated-orcid":false,"given":"Anna","family":"Der\u0119gowska","sequence":"first","affiliation":[{"name":"Faculty of Biotechnology Collegium Medicum University of Rzeszow  Rzeszow 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