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However, clinical translation of many reported hydrogels is often constrained by multi\u2010component formulations, complicated preparation procedures, and insufficient sprayability, which limit conformal coverage on irregular wound beds. Polyitaconate possesses intrinsic antibacterial and anti\u2010inflammatory activities, yet its weak antioxidative properties and lack of thermogelling properties limit its utility in infected wound healing. In this study, we develop a curcumin\u2010modified polyitaconate\u2010based hydrogel (FPIC) that integrates antibacterial, anti\u2010inflammatory, and antioxidant properties. FPIC hydrogel exhibits thermoresponsive gelation, injectability, sprayability, and shear\u2010thinning properties, allowing convenient close contact with complex wound geometries. FPIC hydrogel inhibits bacterial growth, moderates excessive inflammatory responses, and eliminates reactive oxygen species while promoting angiogenesis, thereby facilitating the shift from the inflammatory phase to the proliferative phase of healing. Moreover, FPIC hydrogel enhances collagen deposition, speeds re\u2010epithelialization, and supports balanced tissue remodeling, enabling improved skin regeneration with a lower propensity for fibrosis. These findings establish FPIC hydrogel as a multifunctional and highly bioactive polyitaconate\u2010based hydrogel dressing with strong promise for treating infection\u2010 and inflammation\u2010associated wounds and advancing toward clinical use.<\/jats:p>","DOI":"10.1002\/adhm.71699","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T04:32:17Z","timestamp":1788928337000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Engineering a Multifunctional Sprayable Curcumin\u2010Modified Polyitaconate\u2010Based Hydrogel to Accelerate Methicillin\u2010Resistant\n                    <i>Staphylococcus aureus<\/i>\n                    \u2010Infected Wound Healing"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4574-1411","authenticated-orcid":false,"given":"Min","family":"Wang","sequence":"first","affiliation":[{"name":"Translational Medicine Center 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