{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:52:36Z","timestamp":1792158756869,"version":"4.4.0"},"reference-count":27,"publisher":"Wiley","issue":"38","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In this study, we demonstrate that during diabetic wound healing, interleukin\u201011 (IL\u201011) promotes the M1 polarization of macrophages, which subsequently triggers fibroblast senescence through the enhanced release of pro\u2010inflammatory cytokines IL\u20101\u03b2 and IL\u20106. Notably, Rhoifolin (Rho) effectively inhibits IL\u201011\u2010induced M1 polarization, alleviates the secretion of IL\u20101\u03b2 and IL\u20106, and concurrently promotes the release of choline, thereby mitigating fibroblast senescence. Based on these mechanistic findings, we constructed a targeted delivery system by loading Rho into mesoporous silica nanoparticles and coating them with macrophage membranes (M\u2010Rho). The M\u2010Rho were then incorporated into a poly(L\u2010lysine)\u2010grafted hyperbranched poly(amidoamine) (PLL\u2010\n                    <jats:italic>g<\/jats:italic>\n                    \u2010HPA) hydrogel to fabricate microneedles (Gel@M\u2010Rho MN). This integrated system enables macrophage targeting, controlled drug release, favorable mechanical properties, and excellent biocompatibility. Moreover, the system exhibits potent reactive oxygen species (ROS)\u2010scavenging activity and effectively inhibits the growth of\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    and\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    . In vivo animal studies confirmed that Gel@M\u2010Rho MN significantly promotes M2 macrophage polarization, suppresses fibroblast senescence, and accelerates wound closure, angiogenesis, and collagen deposition. Collectively, this strategy, which modulates macrophage\u2010fibroblast crosstalk, offers a multi\u2010mechanistic synergistic therapeutic approach for diabetic wounds, holding substantial potential for clinical translation.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71700","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T07:38:13Z","timestamp":1789544293000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["PLL\u2010g\u2010HPA Hydrogel Microneedles Loaded With Rhoifolin Target Macrophages to Alleviate Fibroblast Senescence for Diabetic Wound Healing"],"prefix":"10.1002","volume":"15","author":[{"given":"Jiewen","family":"Liao","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Union Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"},{"name":"Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Gan","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Union Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"},{"name":"Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3905-1273","authenticated-orcid":false,"given":"Li","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Union Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"},{"name":"Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration  Wuhan China"},{"name":"Department of Rehabilitation, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan 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Medical College Huazhong University of Science and Technology  Wuhan China"},{"name":"Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guandong","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Pingshan District People's Hospital of Shenzhen Pingshan General Hospital of Southern Medical University  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4860-3017","authenticated-orcid":false,"given":"Mohammad\u2010Ali","family":"Shahbazi","sequence":"additional","affiliation":[{"name":"Department of Biomaterials and Biomedical Technology The Personalized Medicine Research Institute (PRECISION) University Medical Center Groningen University of Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6994-4363","authenticated-orcid":false,"given":"Bobin","family":"Mi","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Union Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"},{"name":"Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration  Wuhan China"},{"name":"Fuzhou Zhixin Future Pharmaceutical Technology Co., Ltd  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengfei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Union Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"},{"name":"Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration  Wuhan 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