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Here, a biomimetic nanovaccine (CDC\/Toy@CCM) is designed by coating toyocamycin (Toy)\u2010loaded redox\u2010responsive carbon dot clusters (CDCs) with homologous cancer cell membranes (CCMs). The obtained nanovaccine exhibits an average size of 70.7\u00a0nm, a high drug loading capacity (12.3%), and a superior photothermal conversion efficiency of 48.7%. The nanovaccine leverages the homologous targeting capacity of CCMs for precise tumor homing, while the disulfide\u2010cross\u2010linked CDCs enable glutathione\u2010triggered drug release specifically within the tumor microenvironment for controlled chemotherapy. Under near\u2010infrared laser irradiation, the CDCs generate robust photothermal ablation of primary tumors, and the combination of chemotherapy and photothermal therapy (PTT) effectively induces immunogenic cell death (ICD), which synergizes the self\u2010adjuvant of CDCs and CCM antigens to generate significant antitumor response to suppress both primary and distant tumors in a bilateral NPC mouse model. In a prophylactic setting, the nanovaccine pre\u2010vaccination generates effective immune protection against subsequent tumor challenge. This work provides a promising \u201cfull\u2010cycle\u201d nanoplatform that synergistically integrates PTT, chemotherapy, and immunotherapy for both NPC treatment and prophylaxis.<\/jats:p>","DOI":"10.1002\/adhm.71703","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T05:52:13Z","timestamp":1788846733000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Self\u2010Adjuvant Photothermal Carbon Dot\u2010Based Nanovaccine for Multimodal Nasopharyngeal Cancer Treatment and Prophylaxis"],"prefix":"10.1002","author":[{"given":"Ruiqi","family":"Ji","sequence":"first","affiliation":[{"name":"State Key Laboratory of Advanced Fiber Materials Shanghai Engineering Research Center of Nano\u2010Biomaterials and Regenerative Medicine College of Biological Science and Medical Engineering Donghua University  Shanghai 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