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Here, we report a nanostarch\u2010functionalized polydimethylsiloxane (NS\u2010PDMS) membrane with potent anti\u2010biofilm efficacy arising from physical topographical interference coupled with metabolism\u2010associated adaptation in surface\u2010attached bacteria. Corn\u2010derived starch nanoparticles (\u223c200\u00a0nm), produced via tunable antisolvent precipitation, were thermally deposited onto PDMS, forming an interwoven porous topography that physically impedes\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    PAO1 adhesion. This microporous architecture enhances surface hydrophilicity and adsorption of extracellular metabolites. Transcriptomic analysis revealed pronounced metabolic disruption in surface\u2010attached cells, particularly in denitrification, leading to impaired proton motive force generation and ATP production. In a CAUTI model, NS\u2010PDMS resisted\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    colonization and alleviated bladder inflammation. Biofilms on NS\u2010PDMS showed enhanced chlorine susceptibility, achieving \u223c96% viability reduction. This work presents a sustainable nanostarch\u2010based anti\u2010biofilm strategy with broad healthcare and food\u2010processing potential.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71704","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T04:21:46Z","timestamp":1788754906000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nanostarch\u2010Functionalized PDMS Membranes Inhibit\n                    <i>Pseudomonas aeruginosa<\/i>\n                    Biofilm via Topographical Interference and Metabolic Perturbation"],"prefix":"10.1002","volume":"15","author":[{"given":"Ziqi","family":"Liu","sequence":"first","affiliation":[{"name":"College of Biosystems Engineering and Food Science Zhejiang University  Hangzhou 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