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To overcome these challenges, we developed a smart, pH\u2010responsive biomaterial platform based on shellac microgels (SCM), derived from a natural, biocompatible insect resin. Combining experimental characterization with finite element analysis, we verified that the densified molecular network of SCM functions as a potent physical barrier that effectively hinders the diffusion of O\n                    <jats:sub>2<\/jats:sub>\n                    , moisture, and UV radiation, as well as physiological assaults (H\n                    <jats:sup>+<\/jats:sup>\n                    and bile salts), protecting the viability of probiotics throughout storage and gastrointestinal transit. Crucially, the pK\n                    <jats:sub>a<\/jats:sub>\n                    \u2010dependent phase transition of SCM enabled precise colon\u2010targeted bio\u2010interface, where its abundant functional groups facilitated strong mucosal anchoring via non\u2010covalent interactions. In a DSS\u2010induced colitis mouse model, this precision\u2010release strategy significantly improved therapeutic outcomes by suppressing the inflammation, restoring gut homeostasis, and repairing the epithelial barrier. This study presents a sustainable, potent, and naturally derived biomaterial strategy for the controlled delivery of sensitive bacterial therapeutics.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71706","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T04:46:40Z","timestamp":1789534000000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["High\u2010Shielding and Colon\u2010Targeted Insect Resin Microgels for Enhanced Probiotic Viability and Colitis Alleviation"],"prefix":"10.1002","volume":"15","author":[{"given":"Shanan","family":"Chen","sequence":"first","affiliation":[{"name":"Research Center of Food Colloids and Delivery of Functionality, College of Food Science and Nutritional Engineering China Agricultural University  Beijing People's Republic of 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