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Herein, a self\u2010gelling supramolecular powder composed of polyethyleneimine (PEI), poly (acrylic acid) (PAA), and \u03b1\u2010lipoic acid (LA) is developed for oral ulcer management.\u00a0Upon contact with saliva, the powder rapidly absorbs water and undergoes instantaneous self\u2010gelation (&lt;5 s), forming a physically cross\u2010linked hydrogel that exhibits robust wet adhesion to oral mucosal tissues. The incorporation of LA enhances the mechanical integrity of the network without increasing swelling, while enabling sustained LA release that imparts intrinsic anti\u2010inflammatory bioactivity. In a murine oral ulcer model, the optimized PEI\/PAA\/1%LA formulation accelerates wound healing, reduces pain\u2010associated behaviors, and suppresses local expression of IL\u20101\u03b2 and TNF\u2010\u03b1. Mechanistically, transcriptomic analysis reveals that LA exerts its anti\u2010inflammatory effects through comprehensive suppression of both classical and noncanonical NF\u2010\u03baB signaling pathways, downregulating Nfkb1, Nfkb2, and downstream inflammatory cytokines. By integrating durable wet adhesion with controlled therapeutic delivery, this supramolecular system offers a clinically translatable strategy for oral mucosal regeneration that addresses both biological healing requirements and patient comfort.<\/jats:p>","DOI":"10.1002\/adhm.71707","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T11:15:58Z","timestamp":1789125358000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["\u03b1\u2011Lipoic Acid\u2010Based Wet\u2010Adhesive Supramolecular Powder Promotes Oral Mucosa Healing by Inhibiting NF\u2010\u03baB Signaling"],"prefix":"10.1002","author":[{"given":"Xinxing","family":"Shuai","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Center For Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; West China Hospital of Stomatology Sichuan University  Chengdu Sichuan 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