{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:53:02Z","timestamp":1792158782976,"version":"4.4.0"},"reference-count":58,"publisher":"Wiley","issue":"38","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100012548","name":"Heilongjiang Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["LBH\u2010223123"],"award-info":[{"award-number":["LBH\u2010223123"]}],"id":[{"id":"10.13039\/100012548","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32501103"],"award-info":[{"award-number":["32501103"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22002096"],"award-info":[{"award-number":["22002096"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2023M730827"],"award-info":[{"award-number":["2023M730827"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Combining glucose oxidase (GOx) with peroxidase\u2010like (POD) nanozymes is a well\u2010established strategy for synergistic starvation and chemodynamic therapy (CDT). However, the low catalytic efficacy of most nanozymes compared to GOx often leads to wasteful accumulation of hydrogen peroxide (H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ), which can inhibit GOx activity and limit the therapeutic effect. Therefore, enhancing the H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    consumption efficiency is critical to unlocking the full potential of this approach. Here, we designed a cobalt\u2010doped mixed\u2010valence copper oxide (Co\u2010Cu\n                    <jats:sub>x<\/jats:sub>\n                    O) nanozyme with metals uniformly dispersed using a polyacrylic acid (PAA) scaffolding method. This nanozyme tightly couples the redox cycles that drive the valence state interconversions of cobalt (Co) and copper (Cu) elements, enabling highly efficient consumption of H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    and glutathione (GSH). While Co provides multi\u2010valent characteristics ideal for Fenton\u2010like reactions, Cu acts not only as a co\u2010catalyst but also triggers cuproptosis. We further installed GOx onto the nanozyme surface, allowing H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    produced by GOx channels to Co\u2010Cu\n                    <jats:sub>x<\/jats:sub>\n                    O active sites, thereby further accelerating the catalytic cascade. In vitro experiments demonstrated effective glucose and H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    depletion with abundant hydroxyl radical (\u00b7OH) generation. When functionalized with hyaluronic acid (HA) for tumor targeting, in vivo experiments demonstrated robust multimodal cell death, confirming the high efficacy of our integrated dual\u2010enzyme platform.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71708","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T04:02:57Z","timestamp":1789099377000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pairing GOx With a Potent H\n                    <sub>2<\/sub>\n                    O\n                    <sub>2<\/sub>\n                    \u2010consuming Co\u2010Cu\n                    <sub>x<\/sub>\n                    O Nanozyme for Starvation\/Cuproptosis\/Chemodynamic Synergistic Therapy"],"prefix":"10.1002","volume":"15","author":[{"given":"Junzhen","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics College of Pharmacy Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics College of Pharmacy Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Research Center for Pharmacoinformatic College of Pharmacy Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guofeng","family":"Ao","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics College of Pharmacy Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiya","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics College of Pharmacy Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics College of Pharmacy Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyang","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics College of Pharmacy Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fujuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics College of Pharmacy Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengying","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics College of Pharmacy Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyuan","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics College of Pharmacy Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics College of Pharmacy Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7739-2140","authenticated-orcid":false,"given":"Jingling","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics College of Pharmacy Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5527-756X","authenticated-orcid":false,"given":"Manjie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics College of Pharmacy Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2583-4493","authenticated-orcid":false,"given":"Bin","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics College of Pharmacy Harbin Medical University  Harbin China"},{"name":"Research Center for Pharmacoinformatic College of Pharmacy Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201907152"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201805664"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5c09544"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2023.141321"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c14433"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202414837"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201053135\u20102"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202401328"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202406683"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpha.2023.09.015"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2021.131671"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2025.138423"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemmater.2c03612"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202403771"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201022286\u2010x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201805368"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1039\/c8cs00718g"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2023.142494"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.7b06814"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1039\/c8cs00457a"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/accountsmr.1c00074"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmt.2021.101357"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mattod.2020.08.020"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010021\u20100085\u20102"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580\u2010020\u20100230\u20103"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celbio.2025.100101"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1039\/d5bm01372k"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2025.138613"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.4c12807"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2023.12.015"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202200331"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apcatb.2023.122558"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202205013"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943\u2010023\u201001732\u2010y"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010025\u201003722\u20102"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2021.130188"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2025.139392"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202207352"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2022.01.074"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201803815"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202112453"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.22203\/eCM.v052a01"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsenergylett.1c00912"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12274\u2010022\u20104258\u2010x"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202413633"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2025.12.021"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202411378"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123566"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c22578"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.2c01004"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202500933"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.0c05287"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2025.170316"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202505911"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2024.06.040"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2025.113838"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c12962"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202309464"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.71708","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.71708","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.71708","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:21:25Z","timestamp":1792156885000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.71708"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,10]]},"references-count":58,"journal-issue":{"issue":"38","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/adhm.71708"],"URL":"https:\/\/doi.org\/10.1002\/adhm.71708","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,10]]},"assertion":[{"value":"2026-01-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71708"}}