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Here, we report a biomimetic, thermo\u2010responsive nanoplatform (AIE\/PCM@OMV) featuring phase\u2010transition\u2010induced deformability to overcome biofilm barriers and treat bacterial pneumonia. The nanoparticles comprise a phase\u2010change material (PCM) core encapsulating an aggregation\u2010induced emission (AIE) phototherapeutic agent and are camouflaged with bacterial outer membrane vesicles (OMVs). The OMV coating enables homologous targeting and preferential accumulation within biofilms derived from the parental strain. Upon 660\u00a0nm laser irradiation, the AIE agent simultaneously generates localized heat and reactive oxygen species, inducing synergistic photothermal\u2013photodynamic bacterial ablation while triggering a solid\u2010to\u2010liquid transition of the PCM core. This phase transition confers dynamic deformability, allowing adaptive structural transformation and deep penetration into biofilms. AIE\/PCM@OMV achieves 99.9% eradication of wild\u2010type\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    biofilms in vitro and reduces pulmonary bacterial burden by 99% in a murine pneumonia model, alleviating lung edema and restoring alveolar architecture. Mechanistically, the therapy reprograms the immune microenvironment by suppressing excessive inflammatory signaling and promoting M2 macrophage polarization. This work establishes a phase\u2010transition\u2010driven deformable biomimetic nanostrategy that integrates homologous targeting, adaptive penetration, and synergistic photothermal\u2013photodynamic therapy for effective treatment of biofilm\u2010associated bacterial pneumonia.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71709","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T04:41:36Z","timestamp":1789360896000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Phase\u2010Transition\u2010Induced Deformable OMV\u2010Camouflaged Nanoparticles Enabling Deep Biofilm Penetration for Photothermal\u2013Photodynamic Eradication of Bacterial Pneumonia"],"prefix":"10.1002","volume":"15","author":[{"given":"Qinyang","family":"Zheng","sequence":"first","affiliation":[{"name":"Key Laboratory of Functional Polymer Materials of Ministry of Education State Key Laboratory of Medicinal 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