{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:53:36Z","timestamp":1792158816267,"version":"4.4.0"},"reference-count":39,"publisher":"Wiley","issue":"38","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Postoperative adhesions remain a major complication after abdominal surgery, and current polymeric barriers often show limited tissue retention and biocompatibility. Here, we establish a water\u2010activated phospholipid barrier strategy for postoperative adhesion prevention by converting a depot\u2010forming phospholipid phase\u2010separation gel (PPSG) into a gram\u2010scale surgical barrier. In this study, solvent identity acts as a functional design determinant rather than a passive solubilizer, governing hydration\u2010triggered gel reinforcement, intraperitoneal residence, and tolerability. Replacing ethanol with propylene glycol strengthened the gel matrix, improved barrier activation, and enabled gram\u2010scale administration without hepatic toxicity associated with ethanol\u2010based PPSG. Mechanistically, the structured phospholipid barrier retained gel\u2010state immunomodulatory activity, attenuating macrophage\u2010driven inflammatory responses and suppressing NF\u2010\u03baB\u2010associated signaling. In a rat peritoneal\u2010cecum abrasion model, propylene glycol\u2010based PPSG completely prevented macroscopic adhesions. Together, these findings establish a water\u2010activated phospholipid barrier platform for converting depot\u2010forming phospholipid systems into active surgical barriers that combine durable physical separation with local immunomodulation.<\/jats:p>","DOI":"10.1002\/adhm.71710","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:12:28Z","timestamp":1789013548000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Water\u2010Activated Phospholipid Phase\u2010Separation Gel as an Immunomodulatory Anti\u2010Adhesion Barrier for Postoperative Adhesion Prevention"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-9354-7236","authenticated-orcid":false,"given":"Jong\u2010Ju","family":"Lee","sequence":"first","affiliation":[{"name":"Yonsei Institute of Pharmaceutical Sciences College of Pharmacy Yonsei University  Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulseung","family":"Sung","sequence":"additional","affiliation":[{"name":"Yonsei Institute of Pharmaceutical Sciences College of Pharmacy Yonsei University  Incheon Republic of Korea"},{"name":"Boston Children's Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeji","family":"Kim","sequence":"additional","affiliation":[{"name":"Yonsei Institute of Pharmaceutical Sciences College of Pharmacy Yonsei University  Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3895-1890","authenticated-orcid":false,"given":"Heesang","family":"Yang","sequence":"additional","affiliation":[{"name":"Yonsei Institute of Pharmaceutical Sciences College of Pharmacy Yonsei University  Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suyeon","family":"Pyo","sequence":"additional","affiliation":[{"name":"Yonsei Institute of Pharmaceutical Sciences College of Pharmacy Yonsei University  Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0901-7530","authenticated-orcid":false,"given":"Byeol","family":"Yun","sequence":"additional","affiliation":[{"name":"Department of Integrative Biotechnology Yonsei University  Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6521-3822","authenticated-orcid":false,"given":"Sung\u2010Joo","family":"Hwang","sequence":"additional","affiliation":[{"name":"Yonsei Institute of Pharmaceutical Sciences College of Pharmacy Yonsei University  Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/13814788.2015.1055466"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1515\/med\u20102016\u20100021"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/1553350610379869"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2007.01358.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2020.08.036"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1258\/jrsm.2010.090378"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/11795549241271715"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12893\u2010024\u201002581\u20102"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/2309499017718908"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2022.12.003"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2020.04.034"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c21938"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6b13184"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-016-1873-9"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13346\u2010023\u201001349\u20100"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp500019p"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2019.01.003"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics16070875"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5MH01280E"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202506940"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202523019"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2023.08.012"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.0c06383"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/19768354.2017.1405072"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0328206"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.1c00046"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/00914037.2021.1876055"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2012.00193"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0209103"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530\u20100277.2010.01324.x"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1210129"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41401\u2010018\u20100085\u20108"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.08.007"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2024.124386"},{"key":"e_1_2_10_36_1","first-page":"1009","article-title":"Pathophysiology and Classification of Adhesions","author":"Z\u00fchlke H. V.","year":"1990","journal-title":"Langenbecks Archiv fur Chirurgie"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0266\u20107681(94)90054\u2010X"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(91)90333-4"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.7b00734"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5162394"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.71710","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.71710","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.71710","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:22:13Z","timestamp":1792156933000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.71710"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,9]]},"references-count":39,"journal-issue":{"issue":"38","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/adhm.71710"],"URL":"https:\/\/doi.org\/10.1002\/adhm.71710","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,9]]},"assertion":[{"value":"2026-05-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71710"}}