{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:53:20Z","timestamp":1792158800752,"version":"4.4.0"},"reference-count":48,"publisher":"Wiley","issue":"38","license":[{"start":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T00:00:00Z","timestamp":1789257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T00:00:00Z","timestamp":1789257600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Ischemic stroke reperfusion injury is driven by oxidative stress and neuroinflammation, but current neuroprotective strategies suffer from poor targeting, limited functionality, and low blood\u2011\u2010brain barrier (BBB) penetration. Herein, a multifunctional nanoplatform (RM@HPAN) is constructed: a hollow mesoporous Prussian blue core with multi\u2011enzyme mimetic activity, loaded with L\u2011arginine and butylphthalide, cloaked with red blood cell membrane for immune evasion, and modified with RVG\u201129 for brain targeting. RM@HPAN exhibits ideal nanosize, pH\u2011responsive release, and robust ROS scavenging. It crosses a BBB model in vitro and boosts neuronal viability under oxygen\u2011\u2010glucose deprivation\/reoxygenation. In a mouse middle cerebral artery occlusion model, RM@HPAN targets ischemic regions, reduces infarct volume from 29.4% to 3.8%, improves neurological scores, and rebalances inflammatory cytokines (TNF\u2011\u03b1, IL\u20116, IL\u201110, TGF\u2011\u03b21). Transcriptomic and proteomic analyses reveal that RM@HPAN suppresses cytokine\u2011cytokine receptor interaction and TNF signaling while activating Rap1\/PI3K\/Akt and Nrf2\/HO\u20111 pathways, thereby inhibiting apoptosis and oxidative stress. Biosafety assessments confirm good biocompatibility. Thus, RM@HPAN offers a promising translatable strategy for ischemic stroke.<\/jats:p>","DOI":"10.1002\/adhm.71712","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T04:44:00Z","timestamp":1789361040000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An Engineered Biomimetic Nanoreactor With Cascade Functions for Targeted and Combinatorial Therapy of Ischemic Stroke"],"prefix":"10.1002","volume":"15","author":[{"given":"Shaofa","family":"Li","sequence":"first","affiliation":[{"name":"Youjiang Medical University For Nationalities Affiliated Southwest Hospital Baise People's Hospital  Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wu","sequence":"additional","affiliation":[{"name":"Youjiang Medical University For Nationalities Affiliated Southwest Hospital Baise People's Hospital  Guangxi 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