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Transcriptomic comparison between control and ALI model groups verified marked dysregulation of genes linked to oxidative stress, inflammation, and endothelial barrier dysfunction. To date, exogenous enzyme supplementation represents a necessary strategy for treating ALI, yet very few options are available to halt excessive ROS accumulation within the critical therapeutic time window. Here, we developed a nanozyme system (SCP@CD) capable of solving this problem by encapsulating autofluorescent Mn\/S\u2010co\u2010doped carbon dots (CDs) into polymer micelles self\u2010assembled via a Schiff base formed by sialic acid\u2010modified chitosan oligosaccharide and protocatechualdehyde. As a targeting ligand, sialic acid enables active targeting of E\u2010selectin on inflamed endothelium, realizing enhanced fluorescence for noninvasive in vivo tracking. Chitosan oligosaccharide linked to sialic acid reduces systemic toxicity, while the Schiff base formed by chitosan oligosaccharide and protocatechualdehyde mediates pH\u2010responsive release via cleavage in acidic inflammatory microenvironments. SCP@CD functions as an exogenous enzyme supplementation via the multi\u2010nanozyme activities of CDs and achieves synergistic anti\u2010inflammatory and endothelial barrier\u2010repairing effects by regulating inflammatory mediators and junctional proteins. This platform offers a novel precision nanomedicine strategy for ALI.<\/jats:p>","DOI":"10.1002\/adhm.71713","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T11:42:07Z","timestamp":1789558927000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Inflammatory Endothelium\u2010Targeted Carbon Dot Nanozymes for Exogenous Enzyme Supplementation and Synergistic Regulation in Acute Lung Injury"],"prefix":"10.1002","volume":"15","author":[{"given":"Yixuan","family":"Gao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese Medicine  Tianjin China"},{"name":"Institute of Traditional Chinese Medicine Tianjin University of Traditional Chinese Medicine  Tianjin 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