{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:52:42Z","timestamp":1792158762619,"version":"4.4.0"},"reference-count":47,"publisher":"Wiley","issue":"38","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20240230"],"award-info":[{"award-number":["BK20240230"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82374223"],"award-info":[{"award-number":["82374223"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Nanoparticles derived from various animals, plants, and microorganisms demonstrate potent application potential in the construction of functionalized pharmaceutic preparations, owing to their special in vivo behavioral and immune\u2010stimulating effects. Yeast cell wall\u2010derived nanoparticles (Ycws) can reverse the tumor immunosuppressive microenvironment via activating various cells related to anti\u2010tumor immunity, while it is difficult to ensure the complete elimination of the treated tumors. Meanwhile, photothermal therapy (PTT) can effectively ablate the irradiated tumors with cell pyroptosis induction, while it has limited effect on the distant unirradiated tumors. Herein, Ycws and near\u2010infrared light II photothermal agent IR1061 had been encapsulated by liposome to obtain Lipo@Ycws\/IR1061 (LYI) for the local ablation of superficial lymphoma and efficient inhibition of the growth of distant tumors. LYI exhibited uniform morphology, good biological stability and outstanding photothermal conversion performance. Furthermore, LYI\u2010mediated PTT triggered cell pyroptosis and eliminated the exposure tumors. Moreover, Ycws together with PTT\u2010induced pyroptosis could reduce the growth of distant tumors via optimizing the tumor immune microenvironment, especially the maturation of DC cells and the anti\u2010tumor polarization of macrophages. This study integrates the efficient local tumor ablation of PTT with the powerful immune adjuvant function of Ycws, providing a biocompatible photothermal\u2010immunotherapy platform for malignant lymphoma.<\/jats:p>","DOI":"10.1002\/adhm.71715","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T04:35:39Z","timestamp":1789619739000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Liposome Loaded With Yeast\u2010Derived Nanoparticles for the Enhanced Photothermal\u2010Immunotherapy of Malignant Lymphoma"],"prefix":"10.1002","volume":"15","author":[{"given":"Yuling","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Hematology Nanjing Drum Tower Hospital Affiliated Hospital of Nanjing University Medical School  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuexue","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hematology Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Hematology Nanjing Drum Tower Hospital Affiliated Hospital of Nanjing University Medical School  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Nanjing Medical Center For Clinical Pharmacy Nanjing Drum Tower Hospital Affiliated Hospital of Nanjing University Medical School  Nanjing China"},{"name":"Department of Colorectal Surgery Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenglin","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1228-869X","authenticated-orcid":false,"given":"Siliang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Nanjing Medical Center For Clinical Pharmacy Nanjing Drum Tower Hospital Affiliated Hospital of Nanjing University Medical School  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1895-0673","authenticated-orcid":false,"given":"Jingyan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Hematology Nanjing Drum Tower Hospital Affiliated Hospital of Nanjing University Medical School  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010024\u201002786\u2010w"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571\u2010024\u201000908\u20109"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010023\u201001407\u20106"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202003572"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.4799"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1411490"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202205641"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21207575"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2023.102109"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25021180"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof9040475"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2022.2096363"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27144616"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201027750\u20102"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943\u2010023\u201001885\u2010w"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3747\/co.27.5223"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202311640"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201046210\u20101"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.2147\/ijn.S373282"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/smtd.202301131"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40820\u2010020\u201000474\u20106"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2022.10.013"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.56482"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1906929116"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matt.2022.08.026"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.34133\/research.0169"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2023.102037"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiotec.2024.11.014"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202202914"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2022.11.002"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13062\u2010023\u201000401\u2010w"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2024.01.021"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010021\u201000507\u20105"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.86855"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1155\/jfbc\/7630023"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S504957"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10020\u2010023\u201000753\u2010z"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c12615"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202310364"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c04819"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201041438\u20109"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr\u201022\u2010311"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.58322"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202306580"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2024.102164"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010024\u201002297\u20108"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964\u2010023\u201001208\u2010y"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.71715","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.71715","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.71715","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:22:09Z","timestamp":1792156929000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.71715"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,16]]},"references-count":47,"journal-issue":{"issue":"38","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/adhm.71715"],"URL":"https:\/\/doi.org\/10.1002\/adhm.71715","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,16]]},"assertion":[{"value":"2026-04-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71715"}}