{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:53:21Z","timestamp":1792158801456,"version":"4.4.0"},"reference-count":56,"publisher":"Wiley","issue":"38","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82474070"],"award-info":[{"award-number":["82474070"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Wound healing is a complex physiological process involving inflammation, tissue regeneration, and remodeling. Designing wound dressings that integrate antioxidant, antibacterial, and hemostatic functions while promoting tissue repair remains a significant challenge. In this study, a multifunctional hydrogel (Rg3@HMS\u2010Gel) was developed by embedding Rg3\u2010loaded gelatin microspheres into a dynamic Schiff base\u2010cross\u2010linked hydrogel composed of oxidized ginseng polysaccharide (OGSP) and carboxymethyl chitosan (CMCS). The physicochemical properties, drug release behavior, biocompatibility, and therapeutic performance of the hydrogel were systematically evaluated through in vitro and in vivo experiments. The Rg3@HMS\u2010Gel demonstrated excellent injectability, self\u2010healing ability, and sustained Rg3 release. It exhibited potent antioxidant and antibacterial activity, promoted HaCaT cell proliferation and migration, and significantly accelerated wound healing in a full\u2010thickness mouse skin defect model. Histological analyses revealed enhanced collagen deposition, reepithelialization, and upregulation of VEGF\u2010A and TGF\u2010\u03b21. Moreover, 16S rRNA sequencing and LEfSe analysis showed that the hydrogel modulated the skin microbiota by increasing beneficial genera (e.g.,\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    ) and reducing pro\u2010inflammatory taxa (e.g.,\n                    <jats:italic>Sphingomonas<\/jats:italic>\n                    ). The Rg3@HMS\u2010Gel hydrogel effectively integrates therapeutic delivery, tissue regeneration, and microbiota modulation, offering a promising strategy for advanced wound management. In conclusion, this work provides new insights into the design of bioactive, multifunctional wound dressings with synergistic healing mechanisms.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71716","type":"journal-article","created":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T04:32:43Z","timestamp":1789187563000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Multifunctional Ginseng Polysaccharide Hydrogel Loaded With Rg3 Microspheres Enhances Wound Healing via Antioxidant, Antibacterial, and Microbiota\u2010Modulating Effects"],"prefix":"10.1002","volume":"15","author":[{"given":"Hao","family":"Chen","sequence":"first","affiliation":[{"name":"College of Chinese Medicinal Materials Jilin Provincial International Joint Research Center for the Development and Utilization of Authentic Medicinal Materials Jilin Agricultural University  Changchun 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Jilin Agricultural University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1376-9676","authenticated-orcid":false,"given":"Shan","family":"Tang","sequence":"additional","affiliation":[{"name":"College of Chinese Medicinal Materials Jilin Provincial International Joint Research Center for the Development and Utilization of Authentic Medicinal Materials Jilin Agricultural University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Chinese Medicinal Materials Jilin Provincial International Joint Research Center for the Development and Utilization of Authentic Medicinal Materials Jilin Agricultural University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010chun","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences Guizhou 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