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However, the lack of effective real\u2010time imaging strategies hinders early diagnosis of sepsis\u2010associated hepatic injury. Herein, we report a biomimetic aggregation\u2010induced emission (AIE) nanoprobe, MM\u2010TPTFA@PEG NPs, for inflammation\u2010targeted imaging of septic liver injury. The AIE luminogenic TPTFA is encapsulated within DSPE\u2010PEG to form stable nanoparticles (NPs), followed by cloaking with primary hepatic macrophage membranes (MM) to confer inflammation\u2010recognition capability. The resulting nanoprobes exhibit uniform size, stable surface properties, and robust fluorescence with minimal signal attenuation under continuous irradiation compared to conventional dyes. Notably, the probe shows negligible reactive oxygen species (ROS) generation and low photothermal conversion, enabling nonperturbative and reliable imaging. In vitro studies demonstrate enhanced fluorescence in lipopolysaccharide (LPS)\u2010activated Kupffer cells, while in vivo imaging reveals preferential accumulation in inflamed hepatic tissues with signal intensity correlating with inflammation severity. Histological analysis and biosafety evaluation further confirm the accuracy and biocompatibility of the system. Collectively, this work presents a biomimetic AIE nanoplatform for sensitive and reliable imaging of inflammatory microenvironments, offering a promising strategy for early diagnosis of sepsis\u2010associated organ injury.<\/jats:p>","DOI":"10.1002\/adhm.71717","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T04:38:50Z","timestamp":1789619930000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Biomimetic Macrophage Membrane\u2013Camouflaged AIE Nanoprobes for Targeted Imaging of Sepsis\u2010Induced Hepatic Inflammation"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5904-0440","authenticated-orcid":false,"given":"Bingwen","family":"Zhu","sequence":"first","affiliation":[{"name":"College of Textile Science and Engineering (International Institute of Silk) Zhejiang Sci\u2010Tech University  Hangzhou Zhejiang China"},{"name":"Department of 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