{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:52:43Z","timestamp":1792158763746,"version":"4.4.0"},"reference-count":66,"publisher":"Wiley","issue":"38","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273814"],"award-info":[{"award-number":["82273814"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>A gelatin\u2010based hydrogel system (GPND@RP) integrating active mechanical contraction, pH\u2010visualized monitoring, and sustained drug delivery was developed for synergistic wound healing. The hydrogel features a rigid\u2013flexible dual\u2010network structure, in which an eight\u2010arm cage\u2010like nano\u2010unit (Octavinyl polyhedral oligomeric silsesquioxane, OV\u2010POSS) serves as a rigid framework to restrict excessive swelling, while a thermoresponsive flexible network comprising by gelatin methacrylate, N\u2010isopropylacrylamide, and OV\u2010POSS undergoes sustained contraction driven by body temperature, enabling active traction and centripetal closure of wound margins. This design achieves a significant shift from traditional passive healing to an active mechanical strategy in the management of wounds. Purple cabbage\u2010derived anthocyanins (PCA) function as a natural visual probe for real\u2010time monitoring of wound pH (2\u201310), and resveratrol\u2010loaded nanovesicles (RNVs, average particle size was 95.81 \u00b1 5.28\u00a0nm) are released in a sustained manner to promote angiogenesis and mitigate excessive inflammation. In vivo animal experiments demonstrated that this multifunctional octahedral cage\u2010architectured gelatin\u2010based hydrogel achieved a 94.89% wound healing rate by day 10, versus 51.08% in the control group. Therefore, with favorable biocompatibility, adhesiveness, and photothermal properties, the GPND@RP hydrogel is a promising strategy for active wound closure and healing.<\/jats:p>","DOI":"10.1002\/adhm.71718","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T06:41:17Z","timestamp":1789022477000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Eight\u2010Arm Cage\u2010Like Nano\u2010Unit\u2010Based Mechanoresponsive Hydrogel Integrating Natural Pigment Probes and Nanovesicles for Promoting Wound Contraction and Healing"],"prefix":"10.1002","volume":"15","author":[{"given":"Zidan","family":"Luo","sequence":"first","affiliation":[{"name":"School of Chemical Engineering Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0220-5779","authenticated-orcid":false,"given":"Sonia","family":"Mukwana","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Wang","sequence":"additional","affiliation":[{"name":"Experimental Animal Center Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhan","family":"Mahmood","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0250-1656","authenticated-orcid":false,"given":"Shun","family":"Yao","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202416267"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.142625"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2025.08.033"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/193293a0"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/btm2.10180"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.102144"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202500150"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202507086"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2025.02.046"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2025.04.010"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010025\u201003274\u20105"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2025.02.030"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.1c25014"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202500688"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celbio.2025.100020"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaw3963"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.07.042"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1517517113"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.101736"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr900201r"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/pi.4757"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.progpolymsci.2011.05.002"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.101837"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2024.115594"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764172.2018.1469767"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202420553"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5c04216"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2014.08.082"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsusc.2023.158578"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2022.122257"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.152875"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2025.124045"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202422188"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202420338"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/bm1015305"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.1c10048"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2024.05.209"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2023.146174"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtnano.2025.100695"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201703086"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp206347u"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsusc.2015.10.193"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.iecr.9b05101"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2025.170049"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioadv.2025.214349"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2007.03.013"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580\u2010024\u201000715\u20101"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202210707"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmatsci.2020.100702"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.200304907"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1039\/c8cp00537k"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2025.343808"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1088\/1361\u20106501\/adf767"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2025.146336"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2025.124530"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2021.02.002"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtcomm.2025.112014"},{"key":"e_1_2_10_59_1","unstructured":"International Organization for Standardization Biological Evaluation of Medical Devices \u2014 Part 4: Selection of Tests for Interactions With Blood.Geneva Switzerland 2002."},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1097\/Fjc.0000000000001602"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsusc.2015.05.108"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.2c02742"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/bit.25686"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep10029"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2021.02.107"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.2147\/Ijn.S460700"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfa.2025.138949"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.71718","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.71718","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.71718","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:22:03Z","timestamp":1792156923000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.71718"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,9]]},"references-count":66,"journal-issue":{"issue":"38","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/adhm.71718"],"URL":"https:\/\/doi.org\/10.1002\/adhm.71718","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,9]]},"assertion":[{"value":"2026-04-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71718"}}