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To address this, we present\n                    <jats:bold>\n                      PAA\u2010Gd\u2010\n                      <jats:italic>\u03b3<\/jats:italic>\n                      \u2010GT\n                    <\/jats:bold>\n                    , an enzyme\u2010activatable dual\u2010modal probe that synergizes MRI's anatomical precision with the exceptional sensitivity of near\u2010infrared fluorescence (NIRF). The probe integrates a chiral Gd\u2010DOTA complex featuring optimized water\u2010exchange kinetics, a poly(acrylic acid) (PAA) scaffold for relaxivity enhancement, and a\n                    <jats:italic>\u03b3<\/jats:italic>\n                    \u2010glutamyl\u2010caged NIRF fluorophore for tumor\u2010selective activation. The probe exhibits a remarkable baseline relaxivity (\n                    <jats:italic>r<\/jats:italic>\n                    <jats:sub>1<\/jats:sub>\n                    ) of 16.1\u00a0mM\n                    <jats:sup>\u22121<\/jats:sup>\n                    s\n                    <jats:sup>\u22121<\/jats:sup>\n                    , which further increases to 21.3\u00a0mM\n                    <jats:sup>\u22121<\/jats:sup>\n                    s\n                    <jats:sup>\u22121<\/jats:sup>\n                    upon GGT\u2010mediated cleavage and subsequent albumin binding, a nearly sevenfold enhancement over clinically used Gd\u2010DOTA (3.0\u00a0mM\n                    <jats:sup>\u22121<\/jats:sup>\n                    s\n                    <jats:sup>\u22121<\/jats:sup>\n                    ). Notably, postactivation intermediates enable prolonged retention within orthotopic gliomas via interaction with local biomolecules, ensuring sustained contrast without compromising biocompatibility. This design affords concurrent tumor delineation via\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>1<\/jats:sub>\n                    \u2010weighted MRI and molecular validation via NIRF, establishing a robust, enzyme\u2010responsive multimodal platform with translational potential for glioma margin identification and image\u2010guided surgery.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71719","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T04:39:07Z","timestamp":1789360747000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A GGT\u2010Activatable Chiral Gadolinium Polymer Probe for Dual\u2010Modal MR\/NIRF Imaging of Glioma"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1784-6827","authenticated-orcid":false,"given":"Xinlan","family":"Zhou","sequence":"first","affiliation":[{"name":"Department 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