{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:59:58Z","timestamp":1790143198507,"version":"4.0.1"},"reference-count":74,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2024QH150"],"award-info":[{"award-number":["ZR2024QH150"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2023QH383"],"award-info":[{"award-number":["ZR2023QH383"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Abnormal wound healing in scar\u2011prone sites remains a clinical challenge, primarily due to excessive inflammation and disorganized extracellular matrix (ECM) remodeling. Herein, we developed an injectable, enzyme\u2011crosslinked hydrogel by incorporating cationic polylysine (PLys) into a transglutaminase\u2011crosslinked gelatin matrix. Mechanistically, the inclusion of PLys not only accelerated gelation kinetics but also enhanced mechanical performance via macromolecular crosslinking, while concurrently imparting self\u2010healing capacity, robust tissue adhesion, and inherent antibacterial activity to the hydrogel. In vitro characterization demonstrated the hydrogel exhibited satisfactory biocompatibility, promoted fibroblast adhesion and spreading, and modulated ECM remodeling by upregulated expression of matrix metalloproteinase (MMPs). Furthermore, the hydrogel exerted significant immunomodulatory effects, as evidenced by increased expression of anti\u2010inflammatory cytokines (IL\u201010, TGF\u2010\u03b2, Arg\u20101) and pro\u2010inflammatory mediators (TNF\u2010\u03b1, IL\u20106), consistent with a controlled early inflammatory stimulus that promotes subsequent resolution. In a rabbit ear hypertrophic scar model, the hydrogel effectively improved scar outcome in scar\u2010prone wounds, as reflected by reduced scar elevation, better\u2010organized collagen architecture, suppressed myofibroblast accumulation, and favorable modulation of both inflammation\u2010related and matrix\u2010remodeling signaling pathways. Collectively, these findings indicate that cationic PLys\u2010compensated hydrogels represent a promising therapeutic strategy for improving wound repair in scar\u2011prone tissues, acting through the coordinated regulation of key cellular and molecular processes.<\/jats:p>","DOI":"10.1002\/adhm.71728","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:01:12Z","timestamp":1790139672000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cationic Polylysine\u2010Compensated Hydrogels Reduce Scar Formation of Scar\u2010Prone Wounds via Immunomodulation and ECM Remodeling"],"prefix":"10.1002","author":[{"given":"Xintong","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Dermatology School of Rehabilitation Sciences and Engineering Qingdao Hospital Qingdao Municipal Hospital University of Health and Rehabilitation Sciences  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baozhen","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of Rehabilitation Sciences and Engineering Qingdao Hospital Qingdao Municipal Hospital University of Health and Rehabilitation Sciences  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingcheng","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of Rehabilitation Sciences and Engineering Qingdao Hospital Qingdao Municipal Hospital University of Health and Rehabilitation Sciences  Qingdao China"},{"name":"School of Pharmacy Qingdao University  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of Rehabilitation Sciences and Engineering Qingdao Hospital Qingdao Municipal Hospital University of Health and Rehabilitation Sciences  Qingdao China"},{"name":"School of Pharmacy Qingdao University  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1002-8181","authenticated-orcid":false,"given":"Wufei","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Department of Medicine 1 Universit\u00e4tsklinikum Erlangen Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg (FAU)  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijie","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Disease Control and Prevention Qingdao Fifth People's Hospital  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8248-9257","authenticated-orcid":false,"given":"Changyuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of Rehabilitation Sciences and Engineering Qingdao Hospital Qingdao Municipal Hospital University of Health and Rehabilitation Sciences  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c04168"},{"issue":"1","key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/s41572-023-00474-x","article-title":"Scars","volume":"9","author":"Jeschke M. G.","year":"2023","journal-title":"Nature Reviews Disease Primers Springer Science and Business Media LLC"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a041242"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2023.0185"},{"key":"e_1_2_10_6_1","doi-asserted-by":"crossref","DOI":"10.1093\/burnst\/tkad009","article-title":"The Application of Corticosteroids for Pathological Scar Prevention and Treatment: Current Review and Update","volume":"11","author":"Sheng M.","year":"2023","journal-title":"Burns & Trauma Oxford University Press (OUP)"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2023.103801"},{"key":"e_1_2_10_8_1","volume-title":"Laser Therapy for Treating Hypertrophic and Keloid Scars, Cochrane Wounds Group","author":"Leszczynski R.","year":"2022"},{"issue":"4","key":"e_1_2_10_9_1","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1089\/wound.2024.0213","article-title":"Treatment of Surgical Scars With Fractional Carbon Dioxide (CO2) Laser: A Randomized Controlled Trial","volume":"15","author":"Chen L.","year":"2025","journal-title":"Advances in Wound Care"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2021.0060"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4TB90085E"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.12.008"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2023.121235"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2021.100127"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202105152"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.07.042"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodhyd.2024.110132"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2024.122011"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.134938"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202411889"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2021.01.001"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.102155"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010022\u201001572\u2010w"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.145239"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010024\u201003003\u20104"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.2c00179"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.3c19556"},{"key":"e_1_2_10_28_1","volume-title":"Concepts, Methods, and Applications[M]. \u7b2c4ed\u7248","author":"Rheology M. A.","year":"2022"},{"key":"e_1_2_10_29_1","volume-title":"Rheology: Principles, Measurements, and Applications[M]","author":"Macosko C. W.","year":"1994"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2022.119336"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.0c01329"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.0c00666"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42995\u2010023\u201000180\u20103"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2021.121204"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2025.123970"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioadv.2022.213152"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1233800"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2023.100682"},{"issue":"36","key":"e_1_2_10_39_1","doi-asserted-by":"crossref","first-page":"40522","DOI":"10.1021\/acsami.2c07952","article-title":"Fibroblasts Close a Void in Free Space by a Purse\u2010String Mechanism","volume":"14","author":"Da Costa A. D. S.","year":"2022","journal-title":"ACS Applied Materials & Interfaces"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2021.118239"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967\u2010025\u201006447\u2010w"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2009.081080"},{"issue":"1","key":"e_1_2_10_43_1","first-page":"122","article-title":"Novel Integrated Multiomics Analysis Reveals a Key Role for Integrin Beta\u2010Like 1 in Wound Scarring","volume":"26","author":"Kim S.\u2010E.","year":"2024","journal-title":"EMBO Reports"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010023\u201006324\u20108"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201033148\u20105"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202308253"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967\u2010025\u201006079\u20100"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/rb\/rbac065"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioadv.2022.213079"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003\u2010020\u201001620\u2010x"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123376"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202105650"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202400457"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2024.124748"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/6037303"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287\u2010020\u201001971\u20106"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202301353"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119483"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2025.116980"},{"issue":"1","key":"e_1_2_10_60_1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/s41572-023-00474-x","article-title":"Scars","volume":"9","author":"Jeschke M. G.","year":"2023","journal-title":"Nature Reviews Disease Primers"},{"key":"e_1_2_10_61_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2023\/3360310","article-title":"IL\u201017: Balancing Protective Immunity and Pathogenesis, B. Xu","volume":"2023","author":"Sun L.","year":"2023","journal-title":"Journal of Immunology Research"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577\u2010022\u201000746\u20109"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2026.1773504"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2024.08.013"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010025\u201003736\u2010w"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2020.11.008"},{"issue":"4","key":"e_1_2_10_67_1","first-page":"1843","article-title":"Signature of the Vascular Tumor Microenvironment as a Marker of the Therapeutic Response to Doxorubicin in a Preclinical Model of Osteosarcoma","volume":"12","author":"Crenn V.","year":"2022","journal-title":"American Journal of Cancer Research"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201046711\u2010z"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.603187"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.09.010"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967\u2010023\u201004217\u20100"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2025.107750"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2025.04.022"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.3c00166"},{"key":"e_1_2_10_75_1","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.2497","article-title":"Enzymatically Crosslinked Gelatin Hydrogel Promotes the Proliferation of Adipose Tissue\u2010derived Stromal Cells","volume":"4","author":"Yang G.","year":"2016","journal-title":"PeerJ"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.71728","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.71728","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.71728","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:01:15Z","timestamp":1790139675000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.71728"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,22]]},"references-count":74,"alternative-id":["10.1002\/adhm.71728"],"URL":"https:\/\/doi.org\/10.1002\/adhm.71728","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,22]]},"assertion":[{"value":"2026-03-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71728"}}