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Herein, inspired by kirigami and origami concepts, we propose a novel approach for fabricating bioceramic scaffolds from pliable, trimmable hydrogel\u2010based ceramic precursors composed of photosensitive hydrogel components and nano\u2010hydroxyapatite. The hydrogel precursor exhibits superior ductility and elasticity, enabling convenient tailoring to the contours of complex bone defects, such as cranium. After sintering, the hydrogel\u2010derived bioceramic scaffolds exhibit ultra\u2010low linear shrinkage (\u223c10%), well\u2010defined structural fidelity, and moderate mechanical properties. In vitro experiments confirmed that the bioceramic scaffolds possess superior biocompatibility and promote osteogenic differentiation, as evidenced by the upregulation of osteogenic genes (Runx2, Alp, Ocn, and Col I). In a rat CSD model, Micro\u2010CT and histological analyses demonstrated that the hydrogel\u2010derived bioceramic scaffolds promoted substantial new bone formation compared with the control group, which was further corroborated by immunohistochemical staining showing upregulated expression of osteogenic\u2010related proteins, including RUNX2, OPN, and OCN. Overall, this work provides a viable strategy for fabricating bioceramic scaffolds that match the geometric contours of bone defects while effectively promoting bone regeneration.<\/jats:p>","DOI":"10.1002\/adhm.71732","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T03:15:33Z","timestamp":1789960533000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Personalized Pliable and Trimmable Hydrogel\u2010Derived Bioceramic Scaffolds for Cranial Bone Regeneration"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0366-795X","authenticated-orcid":false,"given":"Yaoye","family":"Zhao","sequence":"first","affiliation":[{"name":"The Second Hospital &amp; Clinical Medical School Lanzhou University  Lanzhou Gansu China"},{"name":"State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical Physics Chinese Academy of Sciences  Lanzhou Gansu 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