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However, current therapeutic strategies usually lack renal targeting and, critically, neglect to address these systemic comorbidities, particularly the associated cognitive deficits and anxiety\u2010like behaviors. In this study, we developed a biomimetic platform consisting of neutrophils loaded with superparamagnetic iron oxide nanoparticles encapsulating celastrol (termed NSPIOC), as an MRI\u2010visible theranostic system for targeted renal therapy and simultaneous mitigation of associated neuropsychiatric impairments. Systemically administered NSPIOC leverage innate neutrophil chemotaxis to home toward renal inflammatory gradients. Upon infiltration, inflammation\u2010triggered NETosis releases the cargo into vulnerable proximal tubules, while T\n                    <jats:sub>2<\/jats:sub>\n                    \u2010weighted MRI enables real\u2010time monitoring of neutrophil recruitment. Our results demonstrate that NSPIOC effectively restore renal function and inhibits the AKI\u2010to\u2010CKD transition. Importantly, our findings provide new evidence that renal\u2010targeted intervention can alleviate AKI\u2010induced cognitive deficits and anxiety\u2010like behaviors. Mechanistically, restoring renal homeostasis prevents the pathological hyperactivation of glutamatergic neurons in the medial prefrontal cortex (mPFC). This biomimetic platform offers a holistic strategy for managing AKI by simultaneously addressing primary renal injury and remote neurological dysfunction, presenting a promising approach to systemic inflammatory complications.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71733","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T05:47:33Z","timestamp":1790056053000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neutrophil\u2010Mediated Delivery of MRI\u2010Traceable Nanocarriers Ameliorates Acute Kidney Injury and Associated Cognitive Deficits and Anxiety\u2010Like Behaviors"],"prefix":"10.1002","volume":"15","author":[{"given":"Chen","family":"Yang","sequence":"first","affiliation":[{"name":"Medical Imaging Center Department of Electronic Engineering and Information Science University of Science and Technology of China  Hefei Anhui 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