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To address this, we developed an accelerated immunomodulatory matrix reservoir (AIMR) integrating methylgermanane nanosheets (mGeNS) within an active Ca\n                    <jats:sup>2<\/jats:sup>\n                    <jats:sup>+<\/jats:sup>\n                    \u2010crosslinked alginate hydrogel. As an emerging 2D material, mGeNS exhibits exceptional drug\u2010loading capacity and robust near\u2010infrared (NIR) photothermal conversion (efficiency &gt;\u00a060%). Importantly, the hydrogel matrix effectively shields these biodegradable nanosheets from premature in vivo clearance. Upon NIR irradiation, localized hyperthermia softens the hydrogel, triggering the co\u2010release of Ca\n                    <jats:sup>2+<\/jats:sup>\n                    and an mGeNS\u2010delivered immunogenic cell death (ICD) inducer (doxorubicin, DOX). This heat stimulation promotes intracellular Ca\n                    <jats:sup>2+<\/jats:sup>\n                    influx, causing mitochondrial dysfunction that downregulates thermoprotective heat shock proteins (e.g., HSP70), thereby sensitizing tumor cells and amplifying PTT\u2011mediated endoplasmic reticulum stress. Such a synergistic strategy boosts ICD accompanied by the release of numerous damage\u2010associated molecular patterns for dendritic cell maturation and CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell activation. In murine bilateral tumor models, AIMR achieved &gt;\u00a080% local tumor suppression and a 2.43\u2010fold increase in abscopal immune memory over 60 days compared to surgery alone. By synergizing novel 2D mGeNS with active thermosensitive hydrogel, AIMR provides a dual\u2010organelle stress platform for durable photoimmunotherapy.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71736","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T04:35:43Z","timestamp":1789965343000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["NIR\u2010Triggered Methylgermanane Nanosheet\u2010Embedded Hydrogels Enable Cascade Dual\u2010Organelle Stress to Potentiate Cancer Immunotherapy"],"prefix":"10.1002","author":[{"given":"Yingying","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering The Hong Kong Polytechnic University  Kowloon Hong Kong 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