{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:00:36Z","timestamp":1790420436357,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:00:00Z","timestamp":1790380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:00:00Z","timestamp":1790380800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Single\u2010atom nanozymes (SAzymes) have emerged as promising platforms for catalytic therapy owing to their atomic precision and tunable electronic structures. Here, we report an asymmetrically coordinated cobalt SAzyme featuring Co\u2010N\n                    <jats:sub>3<\/jats:sub>\n                    C active sites anchored within a hafnium\u2010based metal\u2013organic framework (Hf\u2010MOF). The engineered HfCoNC nanozyme exhibits significantly enhanced peroxidase\u2010like activity and enables efficient X\u2010ray\u2013activated catalytic immunotherapy. The asymmetric Co\u2010N\n                    <jats:sub>3<\/jats:sub>\n                    C coordination optimizes substrate adsorption and lowers the reaction energy barrier, thereby accelerating the catalytic reaction. In the tumor microenvironment, HfCoNC efficiently converts endogenous H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    into highly cytotoxic hydroxyl radicals (\u2022OH), while low\u2010dose X\u2010ray irradiation further amplifies reactive oxygen species (ROS) production. The resulting oxidative stress induces extensive DNA damage and activates the cGAS\u2010STING signaling pathway. Moreover, the release of Co\n                    <jats:sup>2+<\/jats:sup>\n                    ions, together with the co\u2010delivered STING agonist, further potentiates systemic antitumor immunity, effectively suppressing tumor growth and metastasis. This work provides a promising strategy for developing SAzyme\u2010based platforms for synergistic catalytic radioimmunotherapy.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71740","type":"journal-article","created":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:32:16Z","timestamp":1790418736000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["X\u2010ray\u2010Activated Asymmetric Cobalt Single\u2010Atom Nanozyme Potentiates Catalytic Immunotherapy via Enhanced Peroxidase\u2010Like Activity"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7331-0670","authenticated-orcid":false,"given":"Bo","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Pharmacy Chongqing University Cancer Hospital  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuelin","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Chongqing University Cancer Hospital  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4139-8243","authenticated-orcid":false,"given":"Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Scientific Research Center The First People's Hospital of Zunyi (The Third Affiliated Hospital of Zunyi Medical University)  Zunyi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7585-5925","authenticated-orcid":false,"given":"Xiaoxiao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Chongqing University Cancer Hospital  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongzhong","family":"Wu","sequence":"additional","affiliation":[{"name":"Radiation Oncology Center Chongqing University Cancer Hospital Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8150-2624","authenticated-orcid":false,"given":"Wanyi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Chongqing University Cancer Hospital  Chongqing 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