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Here, we demonstrate that biodegradable polydopamine nanoparticles (PDA NPs) conjugated with transferrin peptides (Tf\u2010PDA NPs), when activated by near\u2010infrared (NIR) laser irradiation, can increase BBB permeability to Tf\u2010PDA NPs both in vitro and in vivo. In vitro, NIR\u2010activated Tf\u2010PDA NPs significantly increased the permeability of brain endothelial cell monolayers compared to bare PDA NPs, without inducing cytotoxicity, compromising monolayer integrity, or triggering macrophage activation. In vivo, intravenous administration of Tf\u2010PDA NPs followed by transcranial NIR laser stimulation resulted in enhanced BBB permeability, as evidenced by increased accumulation of Tf\u2010PDA NPs and Evans Blue dye in the mouse brain parenchyma compared to control groups receiving bare PDA NPs. Collectively, these findings indicate that Tf\u2010PDA NPs represent a promising light\u2010responsive nanocarrier for targeted brain drug delivery. The synergistic combination of Tf peptide conjugation and the photothermal properties of PDA NPs enables efficient brain accumulation without eliciting inflammation, highlighting their potential for the treatment of a broad range of neurological disorders.<\/jats:p>","DOI":"10.1002\/adhm.71746","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T03:51:57Z","timestamp":1790221917000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Near\u2010Infrared Light\u2010Activated Polydopamine Nanoparticles Conjugated With Transferrin Peptides for Enhanced Brain Accumulation"],"prefix":"10.1002","volume":"15","author":[{"given":"Rafaela","family":"Ferr\u00e3o","sequence":"first","affiliation":[{"name":"CNC\u2010Center For Neuroscience and Cell Biology CIBB \u2013 Centre for Innovative Biomedicine and Biotechnology University of Coimbra  Coimbra Portugal"},{"name":"PhD Program in Experimental 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