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Current treatments mitigate single processes but not all at once, limiting their efficacy. To develop an effective multivalent treatment, the small molecule ellagic acid, which inhibits inflammation and oxidative damage while protecting the barrier between blood and spinal cord, was encapsulated within exosomes derived from bone marrow mesenchymal stem cells. These exosomes, by themselves, have been shown to promote neural repair, and loading ellagic acid into them stabilized the drug and increased its bioavailability. The ellagic acid\u2010loaded exosomes (Exos\u2010EA) were formulated into a self\u2010healing chitosan\/hyaluronic acid hydrogel (Exos\u2010EA@CS\/HA\u2010Gel) to prolong their retention and release at the injection site. The resulting Exos\u2010EA@CS\/HA\u2010Gel inhibited lipopolysaccharide\u2010induced inflammatory responses in murine microglial cultures and protected human neuroblastoma cell lines from death due to oxidative stress. In a rat model of spinal cord injury, Exos\u2010EA@CS\/HA\u2010Gel restored the function of the barrier between blood and spinal cord, promoting tissue repair. These results suggest that Exos\u2010EA@CS\/HA\u2010Gel may be effective against spinal cord injury.<\/jats:p>","DOI":"10.1002\/adhm.71750","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:52:32Z","timestamp":1790315552000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sustained Delivery of Exosome\u2010Encapsulated Ellagic Acid via Injectable Self\u2010Healing Hydrogel for Spinal Cord Injury Repair"],"prefix":"10.1002","author":[{"given":"Xiaoling","family":"Zhou","sequence":"first","affiliation":[{"name":"School of Pharmacy Southwest Medical University  Luzhou China"},{"name":"Department of Pharmacy Zhongjiang Maternal and Child Health\u2010Care Hospital  Deyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Pharmacy Southwest Medical University  Luzhou 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