{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T06:49:44Z","timestamp":1791528584373,"version":"4.3.4"},"reference-count":74,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["25ZR1402150"],"award-info":[{"award-number":["25ZR1402150"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Sonodynamic therapy (SDT) demonstrates significant promise for noninvasive therapy of deep solid tumors such as cervical cancer, but its therapeutic efficacy is greatly restricted by low\u2010efficiency sonosensitizers and the immunosuppressive tumor microenvironment (TME). Herein, we report the development of a novel Type\u2010II carbon dot (CD)\/Bi\n                    <jats:sub>2<\/jats:sub>\n                    S\n                    <jats:sub>3<\/jats:sub>\n                    heterojunction for the mild NIR\u2010II photothermal therapy (mPTT) amplified SDT\/nanocatalytic therapy (NCT). The formation of heterojunctions drives the spatial separation of electron\u2013hole pairs under ultrasound excitation, amplifying the generation of reactive oxygen species (ROS) while simultaneously utilizing highly oxidized holes to consume overexpressed GSH. In addition, under 1064 nm laser irradiation, the mild NIR\u2010II photothermal effect generated by CD\/Bi\n                    <jats:sub>2<\/jats:sub>\n                    S\n                    <jats:sub>3<\/jats:sub>\n                    heterojunctions acts as a powerful thermodynamic accelerator, which not only enhances the intrinsic peroxidase (POD) and catalase (CAT) activities, but also relieves hypoxic TME. Based on the cascade amplification of ROS generation and reversal of immunosuppressive TME, CD\/Bi\n                    <jats:sub>2<\/jats:sub>\n                    S\n                    <jats:sub>3<\/jats:sub>\n                    heterojunctions not only achieve high\u2010efficiency tumor eradication but also facilitate the infiltration of T cells in combination with PD\u2010L1 inhibitors, successfully triggering a strong systemic antitumor immune response and inducing persistent immune memory. This work presents an innovative strategy for designing efficient heterojunction nanoplatforms that integrate mild NIR\u2010II PTT, SDT, NCT, and TME regulation functions.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71768","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T06:01:10Z","timestamp":1791525670000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["NIR\u2010II\u2010Responsive Carbon Dot\/Bi\n                    <sub>2<\/sub>\n                    S\n                    <sub>3<\/sub>\n                    Enables Mild Hyperthermia\u2010Amplified Sonocatalytic Therapy Through Heterojunctions Engineering"],"prefix":"10.1002","author":[{"given":"Nan","family":"Wang","sequence":"first","affiliation":[{"name":"Senior Department of Obstetrics and Gynecology Chinese PLA General Hospital  Beijing China"},{"name":"Department of Obstetrics and Gynecology the First Medical 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