{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T12:34:18Z","timestamp":1793104458170,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","issue":"40","license":[{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100794"],"award-info":[{"award-number":["82100794"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974097"],"award-info":[{"award-number":["81974097"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370728"],"award-info":[{"award-number":["82370728"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470771"],"award-info":[{"award-number":["82470771"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82570881"],"award-info":[{"award-number":["82570881"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2026M792234"],"award-info":[{"award-number":["2026M792234"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Acute kidney injury (AKI) and chronic kidney disease (CKD), despite distinct etiologies, share a common pathological axis characterized by reactive oxygen species (ROS) burst, ferroptosis activation, and sustained inflammation. Targeting this ROS\u2013ferroptosis\u2013inflammation cycle represents a promising therapeutic strategy; however, current nanoplatforms are limited by insufficient responsiveness and limited capacity to regulate shared pathological mechanisms across distinct renal disease models. Here, we develop an engineered ROS\u2010responsive nanozyme by integrating diselenide\u2010bridged organosilica, hyaluronic acid (HA)\u2010modified cerium oxide (CeO\n                    <jats:sub>2<\/jats:sub>\n                    ), and a selenium\u2010containing diselenide framework. Under oxidative stress, MON@HA\u2010CeO\n                    <jats:sub>2<\/jats:sub>\n                    undergoes ROS\u2010triggered disassembly, coupling HA\u2010CeO\n                    <jats:sub>2<\/jats:sub>\n                    \u2010mediated ROS scavenging with selenium\u2010related GPX4 restoration to suppress lipid peroxidation, ferroptosis, and inflammatory amplification. In both glycerol\u2010induced AKI and unilateral ureteral obstruction (UUO)\u2010induced renal fibrosis models, the nanozyme significantly improves renal function and attenuates tissue injury, fibrosis, and inflammation. Overall, this work demonstrates a versatile strategy for targeting a shared pathological axis and provides a promising platform for the treatment of diverse renal diseases.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71771","type":"journal-article","created":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:20:55Z","timestamp":1790518855000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An ROS\u2010Responsive CeO\n                    <sub>2<\/sub>\n                    \u2013Selenium Nanozyme Mitigates Renal Injury via Coordinated Ferroptosis Inhibition and Inflammation Resolution"],"prefix":"10.1002","volume":"15","author":[{"given":"Zhiwen","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Nephrology Union Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan 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