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Here, we present an injectable hydrogel system designed to drive integrated bone\u2010vascular regeneration through targeted stem cell homing and localized metabolic rescue. The composite hydrogel, crosslinked from gelatin and oxidized starch, integrates liposome\u2010encapsulated stromal cell\u2010derived factor\u20101 (SDF\u20101) and MXene\u2010enabled GelMA microspheres. This minimally invasive system addresses two critical regenerative phases. First, liposomal SDF\u20101 undergoes controlled release to effectively recruit endogenous bone marrow mesenchymal stem cells (BMSCs). Concurrently, under near\u2010infrared irradiation, the MXene\u2010GelMA microspheres generate mild localized heat stress (40\u201442\u00a0\u00b0C). Crucially, this targeted photothermal therapy acts as a metabolic rescue mechanism; it upregulates heat shock protein 70 (HSP70) in BMSCs to mitigate apoptosis, stimulating endothelial cells to promote robust angiogenesis. In vitro, this cooperative environment significantly enhanced osteogenic differentiation and vascular network formation. In vivo application in a rat critical\u2010sized calvarial defect model validated the hydrogel's therapeutic efficacy. At 8 weeks, the composite system increased the bone volume fraction (BV\/TV) by 21.07% compared to a commercial bone repair material, accompanied by extensive neovascularization. This multifunctional hydrogel establishes a synchronized, translatable strategy for advanced tissue engineering.<\/jats:p>","DOI":"10.1002\/adhm.71772","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T08:35:42Z","timestamp":1791794142000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cooperative Stem Cell Homing and Photothermal Protection Driven by an Injectable Hydrogel for Bone\u2010Vascular Regeneration"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9064-8577","authenticated-orcid":false,"given":"Shaowei","family":"Zheng","sequence":"first","affiliation":[{"name":"Huizhou Central People's Hospital Academy of Medical Sciences Huizhou Central People's Hospital  Huizhou China"},{"name":"Department of Sports Medicine and Rehabilitation Shenzhen Xinhua Hospital Peking University Shenzhen Hospital  Shenzhen China"},{"name":"Hui Zhou\u2010Hong Kong Bone 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