{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:51:08Z","timestamp":1791269468252,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["INST 275\/257\u20101 FUGG"],"award-info":[{"award-number":["INST 275\/257\u20101 FUGG"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["RTG2723 \u201cM\u2010M\u2010M\u201d"],"award-info":[{"award-number":["RTG2723 \u201cM\u2010M\u2010M\u201d"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Forschung, Technologie und Raumfahrt","doi-asserted-by":"publisher","award":["Project 13N15744 \u201cSARS\u2010CoV\u20102Dx\u201d"],"award-info":[{"award-number":["Project 13N15744 \u201cSARS\u2010CoV\u20102Dx\u201d"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The simultaneous circulation of multiple respiratory viruses demands diagnostic platforms capable of rapid, sensitive, and multiplexed detection in complex clinical samples. Here, we present a label\u2010free, multi\u2010channel surface plasmon resonance (MC\u2010SPR) biosensor for simultaneous, real\u2010time detection of three major respiratory viruses. A molecular 2D material, \u223c1\u00a0nm thick azide\u2010terminated carbon nanomembrane (N\n                    <jats:sub>3<\/jats:sub>\n                    \u2010CNM), is used to functionalize the MC\u2010SPR sensor surface, enabling covalent antibody immobilization via click chemistry. This approach provides controlled functionalization of multiple channels with virus\u2010specific antibodies, resulting in robust and reproducible multiplexed detection of the respective antigens. We demonstrate specific detection of SARS\u2010CoV\u20102, Influenza A, and respiratory syncytial virus (RSV) antigens from their mixtures, both in physiological buffer and clinically relevant nasopharyngeal swab matrices, with sensitivity in the pM range, negligible cross\u2010reactivity, and high reproducibility. Unknown analyte concentrations can be directly determined from the SPR data with high accuracy using the respective calibration curves. This work establishes a robust and versatile platform based on molecular 2D materials for the development of multiplexed biosensors and medical diagnostic applications.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71776","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:55:02Z","timestamp":1791266102000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multiplexed Detection of Respiratory Viruses Using Surface Plasmon Resonance Spectroscopy With Ultrathin Carbon Nanomembranes"],"prefix":"10.1002","author":[{"given":"Ghazaleh","family":"Eshaghi","sequence":"first","affiliation":[{"name":"Institute of Physical Chemistry Friedrich Schiller University Jena  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8383-7460","authenticated-orcid":false,"given":"Hamid Reza","family":"Rasouli","sequence":"additional","affiliation":[{"name":"Institute of Physical Chemistry Friedrich Schiller University Jena  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7455-2172","authenticated-orcid":false,"given":"David","family":"Kaiser","sequence":"additional","affiliation":[{"name":"Institute of Physical Chemistry Friedrich Schiller University Jena  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Fischer","sequence":"additional","affiliation":[{"name":"fzmb GmbH Forschungszentrum F\u00fcr Medizintechnik und Biotechnologie  Bad Langensalza Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Frankenfeld","sequence":"additional","affiliation":[{"name":"fzmb GmbH Forschungszentrum F\u00fcr Medizintechnik und Biotechnologie  Bad Langensalza Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0065-412X","authenticated-orcid":false,"given":"Abhishek","family":"Sharma","sequence":"additional","affiliation":[{"name":"BioNavis Ltd.  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