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Herein, we report the synthesis of poly(lipoic acid\u2010co\u2010caffeic acid) (poly(LA\u2010CA)) exhibiting tunable adhesive and mechanical properties according to the polymer configuration. By copolymerization of caffeic acid, thermal polymerization of lipoic acid yields branched copolymer of poly(LA\u2010CA), which is viscous and highly adhesive in wet conditions, while radical polymerization initiated by ammonium persulphate produces elastic and non\u2010adhesive linear poly(LA\u2010CA). Robust asymmetrically adhesive Janus patch is then fabricated by coating a branched poly(LA\u2010CA) layer on a linear copolymer substrate. The patch demonstrates combined performances, particularly showing universal, tough, and sustained adhesion in various environments, together with antioxidant, anti\u2010inflammatory and antibacterial properties. Using the Janus poly(LA\u2010CA) patch, gastric perforations of as large as 1\u00a0cm in diameter are cured in Bama miniature pigs without suturing. The sutureless treatment simultaneously prevents postoperative adhesion and gastric fluid leakage, resulting in 100% survival of the animals, superior to conventional suture repair method. The poly(LA\u2010CA) material is promising for soft tissue injury repair with high clinical translation potential.<\/jats:p>","DOI":"10.1002\/adhm.71781","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:24:58Z","timestamp":1790753098000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Janus\u2010Structured Poly(Lipoic Acid\u2010co\u2010Caffeic Acid) Patch for Asymmetric Underwater Adhesion in Sutureless Gastric Perforation Treatment"],"prefix":"10.1002","author":[{"given":"Shili","family":"Ai","sequence":"first","affiliation":[{"name":"Center of Materials Science and Optoelectronics Engineering College of Materials Science and Opto\u2010Electronic Technology University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenglin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Emergency the First Medical Center Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bowen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Emergency the First Medical Center Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine the Eighth Medical Center of PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feiyu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Emergency the First Medical Center Chinese PLA General Hospital  Beijing 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