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However, incomplete ablation and the immunosuppressive tumor microenvironment (TME) often lead to tumor recurrence and metastasis. Herein, we report a sodium chloride\u2010based in situ tumor vaccine (NaCl@Fe\/Al\u2010LDH@L\u2010Menthol, NLLM ISTVs) designed to enhance MW\u2010metalloimmunotherapy by amplifying ablation\u2010induced adaptive immunity. Upon intravenous administration, MW irradiation turns on the thermal response switch of L\u2010Menthol, which facilitates on\u2010demand in situ release of NaCl from NLLM ISTVs. Subsequently, the high concentrations of Na\n                    <jats:sup>+<\/jats:sup>\n                    \/Cl\n                    <jats:sup>\u2212<\/jats:sup>\n                    induce severe oxidative stress and Ca\n                    <jats:sup>2+<\/jats:sup>\n                    retention in tumor cells. Importantly, NLLM ISTVs combined with MW not only eradicates cancer cells but also induces potent apoptotic cell death, thereby generating robust immunogenic cell death (ICD) signals for boosting adaptive immunity. In vivo studies using primary, distant, and lung\u2010metastatic tumor models demonstrate potent suppression of tumor growth and metastasis with minimal systemic toxicity. These results highlight the dual action of NLLM ISTVs in direct tumor ablation and systemic immune activation, offering a promising strategy for clinical translation. This work provides a proof\u2010of\u2010concept for combining ion\u2010mediated metalloimmunotherapy with MW ablation to achieve robust systemic antitumor immunity.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71784","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:33:35Z","timestamp":1790739215000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["NaCl\u2010Based In Situ Tumor Vaccine via Amplification of Ablation\u2010Induced Adaptive Immunity for Enhanced Microwave\u2010Metalloimmunotherapy"],"prefix":"10.1002","author":[{"given":"Zengzhen","family":"Chen","sequence":"first","affiliation":[{"name":"Interventional Ultrasound Department of Chinese PLA General Hospital Beijing China"},{"name":"State Key Laboratory of Cryogenic Science and Technology Technical Institute of Physics and Chemistry Laboratory of Controllable Preparation and Application of Nanoparticles Technical Institute of Physics and Chemistry Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Jiang","sequence":"additional","affiliation":[{"name":"Interventional Ultrasound Department of Chinese PLA General Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangying","family":"Fan","sequence":"additional","affiliation":[{"name":"Interventional Ultrasound Department of Chinese PLA General Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5394-4062","authenticated-orcid":false,"given":"Sitong","family":"Chen","sequence":"additional","affiliation":[{"name":"Interventional Ultrasound Department of Chinese PLA General Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongyun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Interventional Ultrasound 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