{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:00:01Z","timestamp":1790740801007,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2025MD774163"],"award-info":[{"award-number":["2025MD774163"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Senile osteoporosis (SOP) creates a hostile peri\u2010implant microenvironment characterized by impaired osteogenesis, excessive bone resorption, and persistent oxidative stress, leading to poor osseointegration. Here, we developed a dual\u2010functional titanium surface (Ti\u2010Ta@RS) co\u2010modified with a thioctic acid derivative and risedronate sodium to simultaneously regulate oxidative stress and osteoclast activity. Ti\u2010Ta@RS improved the physicochemical properties of the titanium surface and significantly enhanced BMSC viability, migration, spreading, and osteogenic differentiation under senescence\u2010associated conditions, as evidenced by increased ALP activity, collagen deposition, mineralization, and osteogenesis\u2010related protein expression. Moreover, Ti\u2010Ta@RS effectively reduced intracellular oxidative stress and inhibited RANKL\u2010induced osteoclastogenesis, demonstrating its dual regulatory effects on the pathological SOP microenvironment. In vivo, Ti\u2010Ta@RS markedly promoted peri\u2010implant bone formation, improved trabecular microarchitecture, and enhanced osseointegration in senile osteoporotic rats. Transcriptomic analysis further suggested that these beneficial effects were associated with the regulation of extracellular matrix remodeling, calcium signaling, and cell cycle\u2010related pathways. Collectively, these findings demonstrate that Ti\u2010Ta@RS effectively rebalances the pathological SOP microenvironment by integrating antioxidative regulation with local anti\u2010resorptive activity, thereby providing a promising surface\u2010engineering strategy for enhancing implant osseointegration under senile osteoporotic conditions.<\/jats:p>","DOI":"10.1002\/adhm.71785","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:27:40Z","timestamp":1790738860000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Titanium\u2010Coated Implants With Advanced Antioxidant Properties Are Used in the Design and Development of a Regenerative Repair Strategy for Reversing Senile Osteoporosis"],"prefix":"10.1002","author":[{"given":"Shuaijun","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery Chongqing Municipal Health Commission Key Laboratory of Musculoskeletal Regeneration and Translational Medicine\/Orthopaedic Research Laboratory The First Affiliated Hospital of Chongqing Medical University  Chongqing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics National Clinical Research Center for Child Health and Disorders Ministry of Education Key Laboratory of Child Development and Disorders Chongqing Key Laboratory of Structural Birth Defect and Reconstruction Children's Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Chongqing Municipal Health Commission Key Laboratory of Musculoskeletal Regeneration and Translational Medicine\/Orthopaedic Research Laboratory The First Affiliated Hospital of Chongqing Medical University  Chongqing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongchuan","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Chongqing Municipal Health Commission Key Laboratory of Musculoskeletal Regeneration and Translational Medicine\/Orthopaedic Research Laboratory The First Affiliated Hospital of Chongqing Medical University  Chongqing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Chongqing Municipal Health Commission Key Laboratory of Musculoskeletal Regeneration and Translational Medicine\/Orthopaedic Research Laboratory The First Affiliated Hospital of Chongqing Medical University  Chongqing People's Republic of 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3086-2521","authenticated-orcid":false,"given":"Ai","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Sichuan\u2010Chongqing Joint Key Laboratory of Metabolic Vascular Diseases Chongqing Key Laboratory of Translational Medicine in Major Metabolic Diseases The First Affiliated Hospital of Chongqing Medical University  Chongqing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5561-2775","authenticated-orcid":false,"given":"Kai","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Chongqing Municipal Health Commission Key Laboratory of Musculoskeletal Regeneration and Translational Medicine\/Orthopaedic Research Laboratory The First Affiliated Hospital of Chongqing Medical University  Chongqing People's Republic of 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