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Conventional wound dressings provide passive protection but cannot continuously monitor the dynamic wound microenvironment or deliver adaptive therapy. Unlike previous reviews that independently summarize wound biosensors, responsive biomaterials, or drug\u2010delivery systems, this review critically integrates the complete closed\u2010loop paradigm of intelligent wound management, from single\u2010 and multi\u2010stimuli\u2010responsive sensing to AI\u2010assisted autonomous therapeutic intervention. Chemical and physical sensing modalities are comparatively evaluated based on analytical performance, selectivity, clinical readiness, and translational limitations, while multi\u2010responsive logic\u2010gated platforms are assessed against conventional single\u2010stimulus systems. 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