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This deficiency leads to persistent inflammation, impaired angiogenesis, and excessive reactive oxygen species (ROS) production, forming a vicious cycle to exacerbate tissue damage. Herein, we propose a dual\u2010crosslinked injectable dynamic polysaccharide hydrogel. Leveraging anti\u2010inflammatory oxidized xyloglucan, and carboxymethyl chitosan to construct a first dynamic network based on Schiff\u2010base chemistry, this biomimetic extracellular matrix mimics dynamic changes to promote cell proliferation and resolve inflammation. Furthermore, strontium ions with pro\u2010angiogenic activity and protocatechualdehyde with antioxidant activity serve as crosslinking points for the second dynamic network. This design ensures spatiotemporal alignment between material mechanics and therapeutic action, effectively disrupting the vicious cycle of persistent inflammation, oxidative stress, and impaired angiogenesis in chronic wounds. Additionally, this hydrogel possesses commendable self\u2010healing, tissue\u2010adhesive and antibacterial properties. RNA sequencing analysis revealed that the hydrogel interrupts the inflammatory cascade, modulates immune processes, and accelerates collagen deposition and angiogenesis, promoting chronic wound healing. Collectively, these findings establish a foundation for designing straightforward and multifunctional hydrogel dressings capable of accelerating chronic wound repair by establishing a regenerative microenvironment.<\/jats:p>","DOI":"10.1002\/adhm.71787","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:27:24Z","timestamp":1790738844000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Dynamic Polysaccharide Hydrogel With Reactive Oxygen Species\u2010Scavenging, Antibacterial Activity, and Angiogenesis for Pressure Injury and Diabetic Wound Healing"],"prefix":"10.1002","author":[{"given":"Yuxi","family":"Ma","sequence":"first","affiliation":[{"name":"Institute of Medical Sciences The Second Qilu Hospital &amp; Shandong University Center for Orthopaedics Cheeloo College of Medicine Shandong University  Jinan China"},{"name":"University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0477-3820","authenticated-orcid":false,"given":"Hongyu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Center of Stomatology The Second Qilu Hospital of Shandong University  Jinan China"},{"name":"School and Hospital of Stomatology Cheeloo College of Medicine Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yansheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"An","sequence":"additional","affiliation":[{"name":"University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Qilu Hospital Cheeloo College of Medicine Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2135-1796","authenticated-orcid":false,"given":"Hua","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Emergency The Second Qilu Hospital of Shandong University Cheeloo College of Medicine  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7637-0820","authenticated-orcid":false,"given":"Ningji","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Emergency The Second Qilu Hospital of Shandong University Cheeloo College of Medicine  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0024-4561","authenticated-orcid":false,"given":"Jing","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Medical Sciences The Second Qilu Hospital &amp; 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