{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T10:48:57Z","timestamp":1791542937603,"version":"4.3.4"},"reference-count":40,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82472012"],"award-info":[{"award-number":["82472012"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Chemodynamic therapy (CDT) and brachytherapy face critical challenges, particularly the limited efficiency of Fenton reaction and the insufficient antitumor immunogenicity of brachytherapy. In this study, we employ the metal\u2013organic framework nanocomposite Hf\u2010TCPP@Fe\u2010\n                    <jats:sup>99m<\/jats:sup>\n                    Tc (where TCPP = tetrakis(4\u2010carboxyphenyl) porphyrin and\n                    <jats:sup>99m<\/jats:sup>\n                    Tc = technetium\u201099m) for synergistic long\u2010lasting CDT and immunogenic brachytherapy. Benefiting from the robust interaction between\n                    <jats:sup>99m<\/jats:sup>\n                    Tc\u2010emitted \u03b3\u2010rays and the high\u2010Z element Hf, the secondary electrons generated during brachytherapy not only damage tumor cells but also establish an electron\u2010rich microenvironment that drives the continuous reduction of Fe\n                    <jats:sup>3+<\/jats:sup>\n                    to Fe\n                    <jats:sup>2+<\/jats:sup>\n                    , thereby sustaining a highly efficient Fenton reaction. With the generation of hydroxyl radical persisting for over 12\u00a0h, this synergistic effect reduced cell viability by an additional 28.6% beyond projections, thereby inducing effective immunogenic cell death, activating a systemic antitumor immune response, and inhibiting both primary and metastatic triple\u2010negative breast cancer. Through rational design, this work demonstrates that clinically prevalent nontherapeutic \u03b3\u2010radionuclide can activate long\u2010lasting CDT and immunogenic brachytherapy to enhance antitumor immunogenicity.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71795","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T09:49:36Z","timestamp":1791539376000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["\u03b3\u2010Radionuclide Technetium\u201099M Activated Long\u2010Lasting Chemodynamic Therapy and Immunogenic Brachytherapy for Enhanced Antitumor Immunity"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8910-6817","authenticated-orcid":false,"given":"Naihan","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine National Regional Medical Center Binhai Campus of the First Affiliated Hospital Fujian Medical University  Fuzhou China"},{"name":"Department of Nuclear Medicine the First Affiliated Hospital Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine National Regional Medical Center Binhai Campus of the First Affiliated Hospital Fujian Medical University  Fuzhou China"},{"name":"Department of Nuclear Medicine the First Affiliated Hospital Fujian Medical University  Fuzhou China"},{"name":"School of Medical Imaging Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2516-0951","authenticated-orcid":false,"given":"Lin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine National Regional Medical Center Binhai Campus of the First Affiliated Hospital Fujian Medical University  Fuzhou China"},{"name":"Department of Nuclear Medicine the First Affiliated Hospital Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weibing","family":"Miao","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine National Regional Medical Center Binhai Campus of the First Affiliated Hospital Fujian Medical University  Fuzhou China"},{"name":"Department of Nuclear Medicine the First Affiliated Hospital Fujian Medical University  Fuzhou China"},{"name":"Department of Nuclear Medicine Provincial Clinical Key Specialty of Fujian  Fuzhou China"},{"name":"Fujian Key Laboratory of Precision Medicine For Cancer the First Affiliated Hospital Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21871"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21324"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1950"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c17573"},{"issue":"5","key":"e_1_2_10_6_1","first-page":"386","article-title":"Brachytherapy: An Overview for Clinicians","volume":"69","author":"Chargari C.","year":"2019","journal-title":"Ca\u2010a Cancer Journal For Clinicians"},{"issue":"1","key":"e_1_2_10_7_1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.currproblcancer.2015.10.001","article-title":"Systematic Review of Case Reports on the Abscopal Effect","volume":"40","author":"Abuodeh Y.","year":"2016","journal-title":"Current Problems in Cancer"},{"issue":"2","key":"e_1_2_10_8_1","first-page":"e4103","article-title":"Abscopal Effect of Radiotherapy in the Immunotherapy Era: Systematic Review of Reported Cases","volume":"11","author":"Dagoglu N.","year":"2019","journal-title":"Cureus"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c04189"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2023.110012"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c00977"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202210415"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2022.215004"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202403935"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2023.147464"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2025.164910"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202205692"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.84500"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202506282"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b12873"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.121023"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2023.122446"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304\u20103894(02)00282\u20100"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5c01566"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202400791"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202504612"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2008.12.013"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(19)30326\u20102"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b02400"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2021.101144"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1CS01145F"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360\u20103016(02)04208\u20106"},{"key":"e_1_2_10_33_1","doi-asserted-by":"crossref","unstructured":"K.Smith P.Nakaji T.Thomas et\u00a0al. \u201cSafety and Patterns of Survivorship in Recurrent GBM Following Resection and Surgically Targeted Radiation Therapy: Results From a Prospective Trial \u201dNeuro\u2010Oncology24 no. Suppl 6 (2022):S4\u2013S15 https:\/\/doi.org\/10.1093\/neuonc\/noac133.","DOI":"10.1093\/neuonc\/noac133"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b07570"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202503582"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202421434"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.4c00681"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010026\u201068546\u20106"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2025.127751"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c04375"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568\u2010024\u201000674\u2010x"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.71795","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.71795","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.71795","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T09:49:38Z","timestamp":1791539378000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.71795"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,9]]},"references-count":40,"alternative-id":["10.1002\/adhm.71795"],"URL":"https:\/\/doi.org\/10.1002\/adhm.71795","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,9]]},"assertion":[{"value":"2025-12-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71795"}}