{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:53:40Z","timestamp":1791276820895,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["RO 2511\/11\u20101"],"award-info":[{"award-number":["RO 2511\/11\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"publisher","award":["ORF\u20102026\u2010769"],"award-info":[{"award-number":["ORF\u20102026\u2010769"]}],"id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Incorporating nanofibers into 3D\u2010printed scaffolds is an effective strategy to enhance the physicochemical properties and osteogenic bioactivity of bone tissue engineering constructs. In this study, we developed a composite scaffold featuring a dual\u2010nanofiber interpenetrating network composed of silica (SiO\n                    <jats:sub>2<\/jats:sub>\n                    ) and poly(L\u2010lactic acid)\/gelatin (PLLA\/GEL) nanofibers. SiO\n                    <jats:sub>2<\/jats:sub>\n                    nanofibers were employed to reinforce mechanical properties and release bioactive Si elements, establishing a favorable osteogenic microenvironment. Concurrently, PLLA\/GEL nanofibers were chemically crosslinked with the sodium alginate (SA) matrix to stabilize the scaffold structure. This design effectively addresses the structural instability often observed in single\u2010component inorganic fiber systems. Notably, systematic comparative experiments clarified the distinct contributions of each component. Results indicated that PLLA\/GEL nanofibers primarily contributed to mechanical stability; however, their osteogenic contribution was not significantly superior to PLLA particles. In contrast, SiO\n                    <jats:sub>2<\/jats:sub>\n                    nanofibers exhibited superior bioactivity compared to nanoparticles in inducing osteogenic differentiation and promoting pro\u2010reparative macrophage polarization, leading to enhanced in vivo bone repair. This dual\u2010nanofiber network complementarily improves mechanical stability, modulates inflammation, and promotes osteogenic efficacy, offering a novel strategy for designing high\u2010performance functional bone tissue engineering scaffolds.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71799","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:32:48Z","timestamp":1791275568000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Organic\u2013Inorganic Dual\u2010Nanofiber Interpenetrating Network Scaffolds for Complementary Enhancement of Mechanical Stability and Osteogenic Bioactivity"],"prefix":"10.1002","author":[{"given":"Pengfei","family":"Cai","sequence":"first","affiliation":[{"name":"State Key Laboratory of Advanced Fibers Materials Shanghai Engineering Research Center of Nano\u2010Biomaterials and Regenerative Medicine College of Biological Science and Medical Engineering Donghua University  Shanghai China"},{"name":"G.E.R.N. Research Center for Tissue Replacement Regeneration &amp; Neogenesis, Department of Orthopedics and Trauma Surgery, Faculty of Medicine Medical Center\u2010Albert\u2010Ludwigs\u2010University of Freiburg  Freiburg im Breisgau Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunchun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Stomatology Shanghai Fifth People's Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7855-2407","authenticated-orcid":false,"given":"Chengqiang","family":"Wang","sequence":"additional","affiliation":[{"name":"G.E.R.N. 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