{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T06:52:46Z","timestamp":1791096766281,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:00:00Z","timestamp":1790985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:00:00Z","timestamp":1790985600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    High\u2010performance zirconia ceramics possess excellent mechanical reliability but are limited by biological inertness for load\u2010bearing implant applications. Herein, stereolithography (SLA) additive manufacturing combined with microwave\u2010assisted liquid\u2010phase deposition was developed to construct a \u03b2\u2010tricalcium phosphate (\u03b2\u2010TCP)\u2010containing bioactive interface on Al\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    \/Ce\u2010TZP ceramics. Unlike conventional post\u2010fabrication coating strategies, SLA was utilized as an interface\u2010engineering approach by generating favorable near\u2010surface characteristics for subsequent CaP integration. The SLA\u2010derived interface exhibited a graded CaP\/zirconia transition region of approximately 2\u00a0\u00b5m and enhanced interfacial resistance, with the mean nano\u2010scratch critical load increasing from 10.15 \u00b1 4.93 mN for DP to 21.68 \u00b1 4.18 mN for SLA (\n                    <jats:italic>n<\/jats:italic>\n                    = 3). In vitro evaluations demonstrated low hemolytic response and favorable cytocompatibility, together with enhanced BMSC adhesion and osteogenic differentiation. In vivo rabbit tibial implantation further demonstrated favorable biocompatibility within the evaluated period and improved osseointegration, with 15Ca\u2010TZP implants achieving a bone\u2010implant contact value of 55.6% at 12 weeks. This study presents an interface\u2010engineering strategy that integrates additive manufacturing\u2010derived structural advantages with bioactive functionality for zirconia\u2010based load\u2010bearing implants.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71800","type":"journal-article","created":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T06:22:53Z","timestamp":1791094973000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["In Situ Construction of \u03b2\u2010TCP\u2010Containing Bioactive Interfaces on Additively Manufactured Al\n                    <sub>2<\/sub>\n                    O\n                    <sub>3<\/sub>\n                    \/Ce\u2010TZP Ceramics for Enhanced Osseointegration"],"prefix":"10.1002","author":[{"given":"Bowen","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Advanced Technology For Materials Synthesis and Processing Wuhan University of Technology  Wuhan P. R. China"},{"name":"Biomedical Materials and Engineering Research Center of Hubei Province Wuhan University of Technology  Wuhan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Advanced Technology For Materials Synthesis and Processing Wuhan University of Technology  Wuhan P. R. China"},{"name":"Biomedical Materials and Engineering Research Center of Hubei Province Wuhan University of Technology  Wuhan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2899-8877","authenticated-orcid":false,"given":"Yue","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Stomatology Zhongnan Hospital of Wuhan University  Wuhan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Luo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Advanced Technology For Materials Synthesis and Processing Wuhan University of Technology  Wuhan P. R. China"},{"name":"Biomedical Materials and Engineering Research Center of Hubei Province Wuhan University of Technology  Wuhan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1916-0410","authenticated-orcid":false,"given":"Bo","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Stomatology Zhongnan Hospital of Wuhan University  Wuhan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Foreign Languages Wuhan University of Technology  Wuhan P. R. 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China"},{"name":"Biomedical Materials and Engineering Research Center of Hubei Province Wuhan University of Technology  Wuhan P. R. China"},{"name":"Foshan Xianhu Laboratory of the Advanced Energy Science and Technology Guangdong Laboratory Xianhu Hydrogen Valley  Foshan P. R. China"},{"name":"Sanya Science and Education Innovation Park Wuhan University of Technology  Sanya P. R. 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