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Idebenone (IDBN) shows promise for mitigating IRI, but its efficacy is limited by poor brain accumulation. Moreover, IDBN cannot be visually tracked, making it difficult to confirm whether it reaches the ischemic brain and exerts therapeutic effects. Here, IDBN functionalized with a reactive oxygen species (ROS)\u2010cleavable bond is grafted onto phosphorothioate\u2010modified DNA strands and co\u2010assembled with ultrasmall superparamagnetic iron oxide (USPIO) to form USPIO\u2010IDBN\u2010SNAs, where SNAs stands for spherical nucleic acids. Exploiting upregulated class A scavenger receptors, USPIO\u2010IDBN\u2010SNAs target the ischemic area without targeting modifications and increase local IDBN concentration. Hydrophobic IDBN inside the SNAs limits water access to USPIO clusters, suppressing their contrast\u2010enhancing ability. Under oxidative stress, IDBN is rapidly released and exerts remarkable protection. This release allows USPIO clusters to re\u2010establish contact with water, activating their contrast\u2010enhancing ability on T\n                    <jats:sub>2<\/jats:sub>\n                    \u2010weighted imaging. Collectively, USPIO\u2010IDBN\u2010SNAs provide significant neuroprotection against IRI and offer a magnetic resonance imaging (MRI)\u2010visible platform to monitor IDBN release in the ischemic brain, presenting a promising theranostic approach for precise, trackable stroke therapy.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71802","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:57:41Z","timestamp":1791266261000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Activatable MRI\u2010Trackable Spherical Nucleic Acids for Idebenone Delivery Against Cerebral Ischemia\u2013Reperfusion Injury"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3257-2762","authenticated-orcid":false,"given":"Yan","family":"Wu","sequence":"first","affiliation":[{"name":"Shanghai Institute of Infectious Disease and Biosecurity Department of Radiology Huadong Hospital 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