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In this study, we report a hierarchically structured microparticle system loaded with multiple plant\u2010derived bioactives for psoriasis therapy. The microparticles of sodium alginate (SA) hydrogel with polydopamine (PDA)\u2010modification were fabricated through microfluidics, co\u2010loaded with paeoniflorin (PF) and ginger\u2010derived exosome\u2010like nanoparticles (GELNs). Benefiting from the porous structure of hydrogel and adhesive property of PDA, the microparticles enable stable co\u2010encapsulation of multiple plant\u2010derived bioactives and achieve sustained release at lesion sites, enhancing local bioavailability. The encapsulated PF and GELNs exert complementary anti\u2010inflammatory, antioxidant, and anti\u2010proliferative effects, collectively regulating key pathological processes associated with psoriasis. These results prove that the microparticle\u2010based multiple plant\u2010derived bioactives delivery system provides a safe, cost\u2010effective, and translatable approach for long\u2010term topical treatment of psoriasis, highlighting their therapeutic potential in inflammatory skin diseases.<\/jats:p>","DOI":"10.1002\/adhm.71803","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T03:48:10Z","timestamp":1791431290000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hierarchically Structured Microparticles Encapsulated With Multiple Plant\u2010Derived Bioactives for Psoriasis Therapy"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6849-2379","authenticated-orcid":false,"given":"Dingyuan","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology Nanjing Drum Tower Hospital Clinical College of Nanjing University of 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