{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T11:50:43Z","timestamp":1791373843135,"version":"4.3.1"},"reference-count":64,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFB3810001"],"award-info":[{"award-number":["2023YFB3810001"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52333007"],"award-info":[{"award-number":["52333007"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52203239"],"award-info":[{"award-number":["52203239"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22222905"],"award-info":[{"award-number":["22222905"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Near\u2010infrared (NIR) phosphorescent iridium(III) complexes hold immense promise for biomedical imaging and optoelectronics but suffer from poor quantum yields due to the energy gap law, which amplifies nonradiative decay through vibrational quenching at lower energies. We introduce a molecular rotor engineering strategy that systematically modulates excited\u2010state dynamics by varying the placement of the rotor on chromophoric and ancillary ligands. Restricting rotational motion upon aggregation or in rigid PMMA matrices dramatically suppresses nonradiative pathways, boosting quantum yields from \u223c4% in solution to 65% in 10 wt% PMMA films, with further enhancements in the solid state (12.5%) and aggregates (14.5%). Structural and computational analyses reveal that molecular rotors govern excited\u2010state behavior through configuration interaction between metal\u2010to\u2010ligand charge transfer (\n                    <jats:sup>3<\/jats:sup>\n                    MLCT) and ligand\u2010centered (\n                    <jats:sup>3<\/jats:sup>\n                    LC) states, enabling dynamic population redistribution that tunes radiative and nonradiative channels without requiring discrete state conversion. This aggregation\u2010induced phosphorescence (AIP) mechanism circumvents traditional energy gap limitations. The resulting efficient NIR emission demonstrates selective mitochondrial targeting and potent photodynamic anticancer activity, with aggregation\u2010enhanced quantum yields proving essential for effective\n                    <jats:sup>1<\/jats:sup>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    generation. This rotor engineering approach establishes a versatile design framework for high\u2010performance NIR emitters across therapeutic, imaging, and optoelectronic applications.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71805","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T11:00:27Z","timestamp":1791370827000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Rotor\u2010Controlled Vibronic Coupling Enables Efficient Near\u2010Infrared Phosphorescence in Iridium(III) Complexes for Enhanced Mitochondrial Photodynamic Therapy"],"prefix":"10.1002","author":[{"given":"Wei","family":"He","sequence":"first","affiliation":[{"name":"Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction Department of Chemical and Biological Engineering and State Key Laboratory of Molecular Neuroscience The Hong Kong University of Science and Technology Clear Water Bay  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8299-9450","authenticated-orcid":false,"given":"Tianyu","family":"Li","sequence":"additional","affiliation":[{"name":"Guangdong Basic Research Center of Excellence for Aggregate Science School of Science and Engineering The Chinese University of Hong Kong (Shenzhen)  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5213-7063","authenticated-orcid":false,"given":"Jianyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biobased Transportation Fuel Technology Department of Polymer Science and Engineering. Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6305-9204","authenticated-orcid":false,"given":"Ziyu","family":"Cui","sequence":"additional","affiliation":[{"name":"Guangdong Basic Research Center of Excellence for Aggregate Science School of Science and Engineering The Chinese University of Hong Kong (Shenzhen)  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian Albert","family":"Alfani","sequence":"additional","affiliation":[{"name":"Guangdong Basic Research Center of Excellence for Aggregate Science School of Science and Engineering The Chinese University of Hong Kong (Shenzhen)  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Peng","sequence":"additional","affiliation":[{"name":"Guangdong Basic Research Center of Excellence for Aggregate Science School of Science and Engineering The Chinese University of Hong Kong (Shenzhen)  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faizal","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction Department of Chemical and Biological Engineering and State Key Laboratory of Molecular Neuroscience The Hong Kong University of Science and Technology Clear Water Bay  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5536-0439","authenticated-orcid":false,"given":"Zheng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Guangdong Basic Research Center of Excellence for Aggregate Science School of Science and Engineering The Chinese University of Hong Kong (Shenzhen)  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0728-1178","authenticated-orcid":false,"given":"Zijie","family":"Qiu","sequence":"additional","affiliation":[{"name":"Guangdong Basic Research Center of Excellence for Aggregate Science School of Science and Engineering The Chinese University of Hong Kong (Shenzhen)  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2470-1077","authenticated-orcid":false,"given":"Jianwei","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction Department of Chemical and Biological Engineering and State Key Laboratory of Molecular Neuroscience The Hong Kong University of Science and Technology Clear Water Bay  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacky Wing Yip","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction Department of Chemical and Biological Engineering and State Key Laboratory of Molecular Neuroscience The Hong Kong University of Science and Technology Clear Water Bay  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6866-3877","authenticated-orcid":false,"given":"Ryan Tsz Kin","family":"Kwok","sequence":"additional","affiliation":[{"name":"Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction Department of Chemical and Biological Engineering and State Key Laboratory of Molecular Neuroscience The Hong Kong University of Science and Technology Clear Water Bay  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6534-4953","authenticated-orcid":false,"given":"Parvej","family":"Alam","sequence":"additional","affiliation":[{"name":"Guangdong Basic Research Center of Excellence for Aggregate Science School of Science and Engineering The Chinese University of Hong Kong (Shenzhen)  Shenzhen Guangdong China"},{"name":"Institute of Materials Research Tsinghua Shenzhen International Graduate School Tsinghua University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0293-964X","authenticated-orcid":false,"given":"Ben Zhong","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction Department of Chemical and Biological Engineering and State Key Laboratory of Molecular Neuroscience The Hong Kong University of Science and Technology Clear Water Bay  Hong Kong China"},{"name":"Guangdong Basic Research Center of Excellence for Aggregate Science School of Science and Engineering The Chinese University of Hong Kong (Shenzhen)  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"144","article-title":"Exploring the Photophysical Properties of Iridium(III) Complexes Using TDDFT: A Comprehensive Study","volume":"12","author":"Ren X.","year":"2025","journal-title":"Theoretical Chemistry Accounts"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-55341-4"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202406815"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.2c00206"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c01857"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/bios12121104"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202402906"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2021.102858"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7DT00255F"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.synthmet.2021.116917"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.5c00700"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/ic500070s"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.9b03003"},{"key":"e_1_2_9_15_1","first-page":"11272","article-title":"Bifurcation of Excited\u2010State Population Leads to Anti\u2010Kasha Luminescence in a Disulfide\u2010Decorated Organometallic Rhenium Photosensitizer","volume":"146","author":"Franz J.","year":"2024","journal-title":"Journal of the American Chemical Society"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b04841"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-40716-w"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41377-020-00456-8"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5CP03299G"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121709"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c15150"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1SC00126D"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4DT03424D"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c04585"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2MH00627H"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1039\/b105159h"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c09892"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/agt2.597"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matt.2025.102259"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201904273"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1039\/B712416C"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2dt30771e"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotochemrev.2019.100317"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.5c03387"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5TC01093D"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1063\/5.0200622"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrp.2022.100771"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.2612"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7CP05451C"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.poly.2013.01.045"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5b00263"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119643098"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1039\/C3CS60453E"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5DT01284H"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41570-020-0199-7"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1021\/cm3010453"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/b96858"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/9783527621309"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119007166"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s41061-016-0044-0"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CC08067E"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2cs35171d"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/ange.202514135"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b05302"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6CC10015E"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202413879"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.4c04571"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/agt2.547"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1253\/jcj.65.451"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2005.11.041"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9728.2003.00079.x"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-017-3319-0"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202103359"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/agt2.70181"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2014.2914"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.71805","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.71805","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.71805","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T11:00:28Z","timestamp":1791370828000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.71805"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,7]]},"references-count":64,"alternative-id":["10.1002\/adhm.71805"],"URL":"https:\/\/doi.org\/10.1002\/adhm.71805","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.26434\/chemrxiv-2025-mjhjv","asserted-by":"object"}]},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,7]]},"assertion":[{"value":"2026-03-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71805"}}