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Here, we developed a mechanically self\u2010reinforcing injectable hydrogel in which amino\u2010hydroxyapatite (amHap)\u2010encapsulating spindle\u2010shaped tellurium (Te) nanoparticles (Te@amHap, Team) were embedded within an oxidized alginate\u2010gelatin matrix (Te@amHap\/OG Gel, Team Gel). Team Gel contains dynamic Schiff base bonds, enabling controlled release of Team under joint mechanical forces. Within the acidic microenvironment of the osteoclast sealing zone, Team degrades and releases Te to be oxidized into TeO\n                    <jats:sub>3<\/jats:sub>\n                    <jats:sup>2\u2212<\/jats:sup>\n                    by osteoclast\u2010derived H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    . These ions can react with the thiol\u2010containing residues of F\u2010actin to form Te\u2500S bonds, leading to F\u2010actin degradation to disrupt the sealing zone and suppress bone resorption. Notably, Ca\n                    <jats:sup>2+<\/jats:sup>\n                    from amHap interacts with alginate to form an egg\u2010box secondary crosslinking structure, enhancing the crosslinking density beyond the original Schiff base network, thereby enhancing the mechanical strength of Team Gel and extending its retention time. Acting together, PO\n                    <jats:sub>4<\/jats:sub>\n                    <jats:sup>3<\/jats:sup>\n                    <jats:sup>\u2212<\/jats:sup>\n                    \u2010mediated inhibition of osteoclast differentiation and Te\u2010driven disruption of the mature osteoclast sealing zone suppress osteoclastogenesis and bone resorption. This sealing zone disruption strategy preserves bone quality and joint integrity, suggesting a promising osteoclast\u2010targeted therapy for OA.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71808","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:28:08Z","timestamp":1791275288000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Self\u2010Reinforcing Hydrogel Disrupting Osteoclast Sealing Zone for Bone Erosion Alleviation"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5899-7099","authenticated-orcid":false,"given":"Yilin","family":"Wei","sequence":"first","affiliation":[{"name":"Tianjin Key Laboratory of Drug Delivery &amp; High\u2010Efficiency School of Pharmaceutical Science and Technology Faculty of Medicine Tianjin University  Tianjin 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