{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T09:50:29Z","timestamp":1791539429987,"version":"4.3.4"},"reference-count":345,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN\u20102017\u201006455"],"award-info":[{"award-number":["RGPIN\u20102017\u201006455"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004489","name":"Mitacs","doi-asserted-by":"publisher","award":["IT27833"],"award-info":[{"award-number":["IT27833"]}],"id":[{"id":"10.13039\/501100004489","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Microparticles of hydrogels, also known as microgels, have garnered extensive attention due to their versatile properties and wide range of applications in different fields of science, technology, and medicine. Among the developed technologies to produce microgels, the precise control over fluid handling offered by microfluidics enables particular fine\u2010tuning of the shape, size, and composition of microgels. This article provides a review of recent progress in the development of microfluidic technologies for the fabrication of microgels based on different hydrogel\u2010based biomaterials for diverse practical applications. The fundamental principles of different microfluidic\u2010based techniques for microgel formation are summarized including chip\u2010based, capillary\u2010based, valve\u2010based, three\u2010dimensional printed, and digital microfluidics. Following, strategies for producing microgels from various natural and synthetic polymers using a range of potential crosslinking techniques with varying sizes, structures (water\u2010in\u2010oil, oil\u2010in\u2010water, higher order emulsion, and core\u2010shell), and morphologies (spherical, non\u2010spherical, Janus, and porous) are discussed in detail. Subsequently, the practical applications of microgels produced via microfluidic technologies are summarized across various fields including cell encapsulation, tissue engineering, particle removal, sensors, and food and nutrition, with current challenges and opportunities highlighted to motivate future research in the field.<\/jats:p>","DOI":"10.1002\/adhm.71809","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T09:07:39Z","timestamp":1791536859000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Microfluidic Engineering of Microgels: A Review of Emerging Technologies, Materials, Fabrication Strategies, and Applications"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5957-8067","authenticated-orcid":false,"given":"Afshin","family":"Abrishamkar","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering, Faculty of Engineering McMaster University  Hamilton Ontario Canada"},{"name":"Medical Devices Research Center, Life Sciences Division National Research Council of Canada  Montreal Qu\u00e9bec Canada"},{"name":"Department of Mechanical and Industrial Engineering University of Toronto  Toronto Ontario Canada"},{"name":"Center for Research and Applications in Fluidic Technologies (CRAFT) University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Neely","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Faculty of Engineering McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Pham","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Faculty of Engineering McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nada","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Faculty of Engineering McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8648-9075","authenticated-orcid":false,"given":"Alexis","family":"Larios\u2010Cervantes","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Faculty of Engineering McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben A.","family":"Kertesz","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Faculty of Engineering McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5698-8463","authenticated-orcid":false,"given":"Todd","family":"Hoare","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Faculty of Engineering McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"issue":"5","key":"e_1_2_11_2_1","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202207388","article-title":"Controlled Desiccation of Preprinted Hydrogel Scaffolds Toward Complex 3D Microarchitectures","volume":"35","author":"Cui C.","year":"2023","journal-title":"Advanced Materials"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.coche.2013.12.003","article-title":"Externally Addressable Hydrogel Nanocomposites for Biomedical Applications","volume":"4","author":"Campbell S. 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