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Here, we report dynamic nanocolloidal hydrogels formed from the co\u2010assembly of spheroidal hyperbranched poly(glycerol) (HPG) and soluble albumin nanoparticles (SANs). Functionalization of the HPG with palmitate (a natural ligand of serum albumin) appears to enable self\u2010association of the HPG, as well as its interaction with SANs, to form dynamic networks. The properties of these networks can be tuned by modifying the size of the SAN in addition to other formulation parameters. To highlight the utility of these dynamic hydrogels, we demonstrate (i) in vitro and in vivo release of a model protein therapeutic from these injectable materials, (ii) preliminarily evaluate biocompatibility of these materials in a murine model, and (iii) demonstrate extrusion\u2010based 3D printing using these materials.<\/jats:p>","DOI":"10.1002\/adhm.71810","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T07:41:48Z","timestamp":1791531708000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Protein\u2010Polymer Dynamic Hydrogels Utilizing Native Ligand Binding for Injectable Therapeutic Delivery and 3D Printing"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5316-690X","authenticated-orcid":false,"given":"S. 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