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In recent years, small RNA\u2010based regulatory strategies, such as microRNAs (miRNAs) and small interfering RNAs (siRNAs), have emerged as promising candidates for promoting bone and cartilage regeneration. However, achieving efficient and safe targeted delivery remains a critical challenge. Tetrahedral framework nucleic acids (tFNAs), a type of three\u2010dimensional DNA nanomaterial with precise structure and excellent biocompatibility, serve dual functions as both intelligent delivery carriers and bioactive scaffolds, offering innovative solutions to this challenge. This review systematically outlines the advantages and research progress of tFNAs in this field, with a particular focus on their latest strategies and mechanisms as carriers for loading small RNAs that promote bone and cartilage regeneration. Additionally, the article summarizes cutting\u2010edge investigations into enhancing the targeting ability, stability, and therapeutic efficacy of tFNAs through functional modifications and integration with biomaterials, and discusses the challenges and future directions for clinical translation.<\/jats:p>","DOI":"10.1002\/adhm.71812","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:27:09Z","timestamp":1791271629000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tetrahedral Framework Nucleic Acid\u2010Based Small RNA Delivery: Prospects and Challenges in Bone and Cartilage Regeneration"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9473-2581","authenticated-orcid":false,"given":"Liwei","family":"Fu","sequence":"first","affiliation":[{"name":"Department of Orthopedics Peking University First Hospital  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengang","family":"Ding","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Regenerative Medicine in Orthopedics Key Laboratory of Musculoskeletal Trauma &amp; 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and Anti\u2010Inflammatory Properties for Infected Wound Healing","volume":"16","author":"Qi C.","year":"2024","journal-title":"International Journal of Oral Science"},{"key":"e_1_2_12_100_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.114488","article-title":"Bioswitchable Intracellular Delivery of Small Activating RNA by Tetrahedral Framework Nucleic Acid: Application to p21\u2010Mediated Anti\u2010Tumor Therapy","volume":"389","author":"Liu Y.","year":"2026","journal-title":"Journal of Controlled Release"},{"issue":"17","key":"e_1_2_12_101_1","doi-asserted-by":"crossref","first-page":"19091","DOI":"10.1021\/acsami.1c23869","article-title":"Tetrahedral Framework Nucleic Acids Connected With MicroRNA\u2010126 Mimics for Applications in Vascular Inflammation, Remodeling, and Homeostasis","volume":"14","author":"Ge Y.","year":"2022","journal-title":"ACS Applied Materials & 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Rheumatoid Arthritis","volume":"34","author":"Wang L.","year":"2023","journal-title":"Advanced Functional Materials"},{"issue":"1","key":"e_1_2_12_105_1","doi-asserted-by":"crossref","DOI":"10.1002\/smsc.202500267","article-title":"Nano MiRNA\u2010Functionating Tetrahedral Framework Nucleic Acid for Cartilage\u2010Targeted Ferritinophagy Modulation to Attenuate Temporomandibular Joint Osteoarthritis","volume":"6","author":"Yuan W.","year":"2026","journal-title":"Small Science"},{"issue":"1","key":"e_1_2_12_106_1","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202305622","article-title":"A Novel Bioswitchable miRNA Mimic Delivery System: Therapeutic Strategies Upgraded From Tetrahedral Framework Nucleic Acid System for Fibrotic Disease Treatment and Pyroptosis Pathway Inhibition","volume":"11","author":"Jiang Y.","year":"2024","journal-title":"Advanced 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Reviews"},{"issue":"4","key":"e_1_2_12_110_1","article-title":"TSHR\u2010Targeting Nucleic Acid Aptamer Treats Graves' Ophthalmopathy via Novel Allosteric Inhibition","volume":"13","author":"Zhang Y.","year":"2026","journal-title":"Advanced Science"},{"issue":"30","key":"e_1_2_12_111_1","doi-asserted-by":"crossref","first-page":"42717","DOI":"10.1021\/acsami.5c07913","article-title":"DNA Tetrahedron Functionalized Microneedles Blocking IL\u20106 to Promote Skin Wound Healing","volume":"17","author":"Wang Y.","year":"2025","journal-title":"ACS Applied Materials & Interfaces"},{"issue":"22","key":"e_1_2_12_112_1","doi-asserted-by":"crossref","first-page":"25825","DOI":"10.1021\/acsami.1c07297","article-title":"Enhanced Penetrability of a Tetrahedral Framework Nucleic Acid by Modification With iRGD for DOX\u2010Targeted Delivery to Triple\u2010Negative Breast Cancer","volume":"13","author":"Liu M.","year":"2021","journal-title":"ACS Applied Materials & 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Regeneration","volume":"26","author":"Chang C.\u2010C.","year":"2018","journal-title":"Molecular Therapy"},{"issue":"9","key":"e_1_2_12_119_1","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/nrg2843","article-title":"The Widespread Regulation of microRNA Biogenesis, Function and Decay","volume":"11","author":"Krol J.","year":"2010","journal-title":"Nature Reviews Genetics"},{"issue":"2","key":"e_1_2_12_120_1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.molmed.2011.11.005","article-title":"Epigenomic and microRNA\u2010Mediated Regulation in Cartilage Development, Homeostasis, and Osteoarthritis","volume":"18","author":"Goldring M. 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