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Emerging evidence implicates keratinocyte ferroptosis as a critical pathological mechanism, whereby oxidative epidermal damage and elevated levels of cell\u2010free DNA (cfDNA) amplify immune dysregulation and sustain chronic psoriatic inflammation. Here, we developed a dual\u2010action microneedle system (CAD), with needle tips composed of guanidine\u2010functionalized chitosan and deferoxamine (DFO), designed to eliminate pro\u2010inflammatory cfDNA while locally releasing DFO for iron chelation. In an imiquimod\u2010induced psoriasis mouse model, CAD markedly alleviated psoriatic symptoms, reducing the psoriasis area and severity index score by approximately 50% compared with the model group and demonstrating superior therapeutic efficacy to clinically used calcipotriol. Further studies revealed that CAD depleted accumulated iron and inflammatory cfDNA in lesioned skin, alleviating oxidative stress and suppressing ferroptosis, inhibiting the inflammatory cascade, and maintaining immune homeostasis for effective psoriasis treatment. This study presents a dual\u2010action microneedle therapy for psoriasis that alleviates psoriasis by modulating keratinocyte ferroptosis and scavenging cfDNA to restore inflammatory homeostasis, providing a promising foundation for the development of mechanism\u2010guided combination therapies for psoriasis. Future work will further optimize the formulation for clinical translation and explore its therapeutic potential for other ferroptosis\u2010related inflammatory skin disorders.<\/jats:p>","DOI":"10.1002\/adhm.71816","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T04:37:51Z","timestamp":1791866271000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Dual\u2010Action Microneedle Patch Inhibiting Keratinocyte Ferroptosis and Scavenging Cell\u2010Free DNA for Psoriasis Treatment"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6340-8489","authenticated-orcid":false,"given":"Jinmin","family":"Ye","sequence":"first","affiliation":[{"name":"State Key Laboratory of Vaccines for Infectious Diseases Xiang an Biomedicine Laboratory School of Public Health Xiamen University  Xiamen 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