{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T10:54:21Z","timestamp":1791456861634,"version":"4.3.4"},"reference-count":60,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2411300"],"award-info":[{"award-number":["2023YFC2411300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32371467"],"award-info":[{"award-number":["32371467"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Volumetric muscle loss (VML) results in irreversible muscle impairment, necessitating tissue\u2010matched electrostimulation scaffolds for clinical repair. Here, we report a biointegrated hydrogel that leverages a piezoelectric\u2010conductive organic heterojunction to deliver self\u2010powered electrical cues directly to the injury site. The heterojunction comprises a piezoelectric metal\u2013organic framework (MOF) coated with conductive polypyrrole (PPy), forming a stable p\u2013n organic heterojunction with an intrinsic built\u2010in electric field. Unlike inorganic piezoelectrics, the organic MOF\u2010PPy features an ultralow elastic modulus, porous architecture, and exceptional deformability, delivering robust piezoelectric output under mild muscular contraction. These MOF\u2010PPy is then covalently integrated into a silk fibroin network via in situ photopolymerization to produce the MOF\u2010PPy@Sil hydrogel, where covalent conjugation ensures efficient stress transfer, maximizing piezoelectric signal generation. The piezoelectric and conductive cues significantly promote cell viability and migration, upregulate myogenic markers, and enhance maturation of organized muscle fibers. In a rat tibialis anterior VML model, MOF\u2010PPy@Sil drives myofiber formation, structural reconstruction, and near\u2010complete restoration of hindlimb motor function. Mechanistically, the endogenous electroactive niche upregulates myogenic and metabolic pathways, while mitigating inflammatory responses that impede muscle regeneration. This work presents a piezoelectric\u2010conductive hydrogel paradigm that harnesses the deformability of organic heterojunctions to generate a mechano\u2010electrical microenvironment for regenerative medicine.<\/jats:p>","DOI":"10.1002\/adhm.71818","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T10:25:10Z","timestamp":1791455110000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Highly Deformable Organic Heterojunctions Empower Piezoelectric\u2010Conductive Hydrogels for Functional Volumetric Muscle Regeneration"],"prefix":"10.1002","author":[{"given":"Tianyu","family":"Gao","sequence":"first","affiliation":[{"name":"Institute of Biomedical Engineering College of Medicine Key Laboratory of Advanced Technologies of Materials Ministry of Education Southwest Jiaotong University  Chengdu P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering College of Medicine Key Laboratory of Advanced Technologies of Materials Ministry of Education Southwest Jiaotong University  Chengdu P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuying","family":"Ren","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering College of Medicine Key Laboratory of Advanced Technologies of Materials Ministry of Education Southwest Jiaotong University  Chengdu P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering College of Medicine Key Laboratory of Advanced Technologies of Materials Ministry of Education Southwest Jiaotong University  Chengdu P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"He","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering College of Medicine Key Laboratory of Advanced Technologies of Materials Ministry of Education Southwest Jiaotong University  Chengdu P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering College of Medicine Key Laboratory of Advanced Technologies of Materials Ministry of Education Southwest Jiaotong University  Chengdu P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1312-0215","authenticated-orcid":false,"given":"Xiaohong","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering College of Medicine Key Laboratory of Advanced Technologies of Materials Ministry of Education Southwest Jiaotong University  Chengdu P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202506476","article-title":"Zn\u2010DHM Nanozymes Enhance Muscle Regeneration Through ROS Scavenging and Macrophage Polarization in Volumetric Muscle Loss Revealed by Single\u2010Cell Profiling","volume":"35","author":"Feng X. 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