{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:43:09Z","timestamp":1792658589722,"version":"4.5.0"},"reference-count":62,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Osteoarthritis (OA) is a common age\u2010related degenerative joint disorder with no effective disease\u2010modifying drugs. Cellular senescence and mitochondrial dysfunction that disrupt chondrocyte homeostasis are key drivers of OA initiation and progression. Here, we develop mitochondria\u2010targeted supramolecular nanoparticles (EG NPs) self\u2010assembled from Epigallocatechin\u20103\u2010gallate (EGCG) and L\u2010Glutamic acid (L\u2010Glu), enabling efficient scavenging of mitochondrial reactive oxygen species (mtROS) through targeted delivery and ultimately restoring mitochondrial homeostasis. This leads to reduced DNA damage, inhibition of the NF\u2010\u03baB inflammatory signaling pathway, and attenuation of cellular senescence along with its associated inflammatory senescence\u2010associated secretory phenotype (SASP). Simultaneously, mitochondria\u2010targeted EG NPs promote mitochondrial inner and outer membrane fusion and biogenesis by upregulating fusion markers and activating the AMPK pathway, enhancing energy supply, alleviating cellular senescence, and promoting matrix synthesis in chondrocytes. In vivo experiments in a mouse OA model prove that EG NPs markedly suppress synovial inflammation, alleviate articular cartilage damage and matrix degradation, and ameliorate abnormal subchondral bone remodeling, thereby preserving cartilage structural integrity and effectively slowing OA progression. This multifunctional mitochondria\u2010targeted nanoplatform, centered on restoring mitochondrial homeostasis, precisely modulates the function of senescent chondrocytes and alleviates their senescent phenotype, establishing a promising new paradigm for OA therapy and opening new avenues for nanotechnology\u2010based interventions in aging\u2010related diseases.<\/jats:p>","DOI":"10.1002\/adhm.71831","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:34:15Z","timestamp":1792658055000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mitochondria\u2010Targeted Supramolecular Nanoparticles Alleviate Cellular Senescence by Restoring Mitochondrial Homeostasis in Osteoarthritis"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-3249-2222","authenticated-orcid":false,"given":"Yuan","family":"Hui","sequence":"first","affiliation":[{"name":"Department of 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