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We developed an ultraviolet B (UVB) light\u2010triggered scaffold, 1,4,2\u2010dioxazol\u20105\u2010thione (DOT), for the controlled release of hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S), a pivotal endogenous gaseous signaling molecule with promise for anti\u2010inflammatory and antioxidant therapies. In the DOT scaffold, the kinetics for H\n                    <jats:sub>2<\/jats:sub>\n                    S release are efficiently tuned by fine\u2010adjusting the electronic properties. Upon photoirradiation, DOT releases carbonyl sulfide (COS), which is rapidly converted to H\n                    <jats:sub>2<\/jats:sub>\n                    S by carbonic anhydrase (CA). Furthermore, the DOT platform is conjugated to the active pharmaceutical ingredient pterostilbene (PTE) to afford a hybrid prodrug, PTE\u2010DOT. Under UVB irradiation at 308\u00a0nm, a standard wavelength for psoriasis phototherapy, PTE\u2010DOT simultaneously released H\n                    <jats:sub>2<\/jats:sub>\n                    S and PTE, thereby exerting combined anti\u2010inflammatory and antioxidant effects in vivo. In the psoriasis mouse model, PTE\u2010DOT effectively reduced epidermal thickening and hyperkeratosis, suppressed the production of key psoriatic inflammatory cytokines, and inhibited the differentiation of Th17 cells in the spleen. Thus, the photo\u2010controlled prodrug strategy provides a platform for designing smart drug delivery systems to ameliorate psoriasis\u2010like skin inflammation.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71835","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T03:40:07Z","timestamp":1791776407000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Photo\u2010Controlled Treatment for Psoriasis\u2010Like Skin Lesions by UVB\u2010Photoactivated Hydrogen Sulfide Donors and Pterostilbene"],"prefix":"10.1002","author":[{"given":"Jia","family":"Lin","sequence":"first","affiliation":[{"name":"School of Chemistry and Molecular Engineering East China Normal University  Shanghai P. R. 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